Carbosulfan-d18|1189903-75-0|-陌孚医药/Medlife

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Carbosulfan-d18

目录号: PL14531

CAS No. :1189903-75-0

商品编号	规格	价格	会员价	是否有货	数量
PL14531-1mg	1mg	询价	询价
PL14531-10mg	10mg	询价	询价

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中文名称	Carbosulfan-d18
中文别名	苯甲醇,4-氨基-3-氯-;丁硫克百威-d18;丁硫克百威 d18
英文名称	Carbosulfan-d18
英文别名	Carbosulfan-d18;(2,2-dimethyl-3H-1-benzofuran-7-yl) N-[bis(1,1,2,2,3,3,4,4,4-nonadeuteriobutyl)amino]sulfanyl-N-methylcarbamate
Cas No.	1189903-75-0
分子式	C₂₀H₃₂N₂O₃S
分子量	380.54
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情	Carbosulfan-d₁₈ 是 Carbosulfan 的氘代物。Carbosulfan强效抑制CYP3A4, 适度抑制CYP1A1/2和CYP2C19。
生物活性	Carbosulfan-d 18 is the deuterium labeled Carbosulfan. Carbosulfan inhibited relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers). Carbosulfan activation is predominantly catalyzed in humans by CYP3A4.
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Abass K, et al. Metabolism of carbosulfan II. Human interindividual variability in its in vitro hepatic biotransformation and the identification of the cytochrome P450 isoforms involved. Chem Biol Interact. 2010 May 14;185(3):163-173.

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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