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Ablukast

(Synonyms: 阿鲁司特; Ro 23-3544)

目录号: PL13332 纯度: ≥99%

Ablukast (Ro 23-3544) 是一种特异性的白三烯受体拮抗剂。Ablukast 可有效减少 LTC4 和抗原诱导的支气管狭窄。Ablukast 是一种 LTD4 受体拮抗剂.

CAS No. :96566-25-5

商品编号	规格	价格	会员价
PL13332-1mg	1mg	¥197.00	请登录
PL13332-5mg	5mg	¥553.00	请登录
PL13332-10mg	10mg	¥901.00	请登录
PL13332-25mg	25mg	¥1775.00	请登录
PL13332-50mg	50mg	¥2495.00	请登录
PL13332-100mg	100mg	¥3365.00	请登录
PL13332-10mM*1mLinDMSO	10mM*1mLinDMSO	¥4420.00	请登录
PL13332-1 mL x 10 mM (in DMSO)		¥601.00	请登录

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中文名称	Ablukast
中文别名	阿鲁司特
英文名称	Ablukast
英文别名	2H-1-Benzopyran-2-carboxylicacid,6-acetyl-7-[[5-(4-acetyl-3-hydroxy-2-propylphenoxy)pentyl]oxy]-3,4-dihydro-;6-acetyl-7-[5-(4-acetyl-3-hydroxy-2-propylphenoxy)pentoxy]-3,4-dihydro-2H-chromene-2-carboxylic acid
Cas No.	96566-25-5
分子式	C₂₈H₃₄O₈
分子量	498.56
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	Ablukast (Ro 23-3544) 是一种特异性的白三烯受体拮抗剂。Ablukast 可有效减少 LTC4 和抗原诱导的支气管狭窄。Ablukast 是一种 LTD4 受体拮抗剂.

产品详情	Ablukast (Ro 23-3544) 是一种特异性的白三烯受体拮抗剂。Ablukast 可有效减少 LTC4 和抗原诱导的支气管狭窄。Ablukast 是一种 LTD4 受体拮抗剂.
生物活性	Ablukast (Ro 23-3544) is a specific and active leukotriene receptor antagonist. Ablukast effectively reduces LTC4- and antigen-induced bronchoconstriction. Ablukast is LTD4 receptor antagonist.
性状	Solid
IC50 & Target[1][2]	LTD4
体外研究(In Vitro)	Ablukast (Ro 23-3544) is tested for its efficacy in modulating dinitrofluorobenzene (DNFB)-induced allergic and croton oil-induced irritant contact dermatitis in mouse ears. Treatment shortly after elicitation of the dermatitis, and for up to 5 days thereafter, was moderately effective in suppressing DNFB-induced ear swelling in a dose-dependent fashion. Daily pre-treatment of the ears for 1 week causes a more marked reduction of DNFB-induced ear swelling during the first 48 h after elicitation. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Ablukast (Ro 23-3544) is tested for its efficacy in modulating dinitrofluorobenzene (DNFB)-induced allergic and croton oil-induced irritant contact dermatitis in mouse ears. Treatment shortly after elicitation of the dermatitis, and for up to 5 days thereafter, was moderately effective in suppressing DNFB-induced ear swelling in a dose-dependent fashion. Daily pre-treatment of the ears for 1 week causes a more marked reduction of DNFB-induced ear swelling during the first 48 h after elicitation. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. M ODonnell, et al. Pharmacological profile of Ro 23-3544, a new aerosol active leukotriene receptor antagonist. Adv Prostaglandin Thromboxane Leukot Res. 1987;17A:512-8. [2]. T Rosenbach, et al. Studies on the role of leukotrienes in murine allergic and irritant contact dermatitis. Br J Dermatol. 1988 Jan;118(1):1-6.

溶解度数据	In Vitro: DMSO : 100 mg/mL (200.58 mM; Need ultrasonic)配制储备液

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[1]. M ODonnell, et al. Pharmacological profile of Ro 23-3544, a new aerosol active leukotriene receptor antagonist. Adv Prostaglandin Thromboxane Leukot Res. 1987;17A:512-8.
[2]. T Rosenbach, et al. Studies on the role of leukotrienes in murine allergic and irritant contact dermatitis. Br J Dermatol. 1988 Jan;118(1):1-6.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Ablukast

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