Impurity C of Calcitriol|86307-44-0|(PRE-骨化三醇PTAD加合物)-陌孚医药/Medlife

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Impurity C of Calcitriol (Synonyms: PRE-骨化三醇PTAD加合物)

目录号: PL12538 纯度: ≥99%

CAS No. :86307-44-0

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中文名称	Impurity C of Calcitriol
中文别名	PRE-骨化三醇PTAD加合物;预骨化三醇PTAD加合物;骨化三醇前体的三唑啉加合物;骨化三醇杂质 C
英文名称	Impurity C of Calcitriol
英文别名	pre-Calcitriol PTAD Adduct;pre-Calcitriol PTAD Adduct (Mixture of Diastereomers);1H,5H-Cyclopenta[f][1,2,4]triazolo[1,2-a]cinnoline-1,3(2H)-dione, 11-(3,5-dihydroxy-2-methyl-1-cyclohexen-1-yl)-4a,6,6a,7,8,9,9a,11-octahydro-7-(5-hydroxy-1,5-dimethylhexyl)-6a-methyl-2-phenyl-, [4aR-;pre-Calcitriol PTAD Adduct (Mixture of Diastereomers);Impurity C of Calcitriol
Cas No.	86307-44-0
分子式	C₃₅H₄₉N₃O₅
分子量	591.78
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	Impurity C of Calcitriol是Calcitriol的杂质，Calcitriol是维生素D3的活性代谢物，能激活维生素D受体。
生物活性	Impurity C of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR). IC50 value: Target: vitamin D receptor Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) displays calcemic actions. Calcitriol stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Calcitriol (1,25-Dihydroxyvitamin D3; Rocaltrol )exhibits antitumor activity; Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.
性状	Solid
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Canalejo et al (2000) The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865. Beer and Myrthue (2004) [2]. Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373. [3]. Krishnan AV, Swami S, Feldman D.Equivalent anticancer activiti

溶解度数据	In Vitro: DMSO : 50 mg/mL (84.49 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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