Lexacalcitol|131875-08-6|(来沙骨化醇; KH1060)-陌孚医药/Medlife

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Lexacalcitol (Synonyms: 来沙骨化醇; KH1060)

目录号: PL12562 纯度: ≥99%

CAS No. :131875-08-6

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中文名称	Lexacalcitol
中文别名	来沙骨化醇
英文名称	Lexacalcitol
英文别名	Lexacalcitol;(1S,3R,5Z),7aalpha))-(5Z,7E,20R)-20-((4-Ethyl-4-hydroxyhexyl)oxy)-9,10-secopregna-5,7,10(19)-triene-1alpha,3beta-diol;(1R,3S,5Z)-5-[(2E)-2-[(1S,3aS,7aS)-1-[(1R)-1-(4-ethyl-4-hydroxyhexoxy)ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol;20-epi-22-oxa-24a,26a,27a-tri-homo-1,25-dihydoxyvitamin D3;KH 106;KH 1060;KH-1060;L-3-HYDROXY-N-METHYLMORPHINAN;Levo-dromoran (tn);LEVORPHANOL TARTRATE;Levorphanol Tartrate (CII),USP;Levorphanol Tartrate CII (500 mg);LEVORPHANOL TARTRATE DIHYDRATE;levorphanol tartrate methanol solution;LEVORPHANOL TARTRATE SALT;LEVORPHANOLTARTRATE,USP
Cas No.	131875-08-6
分子式	C₂₉H₄₈O₄
分子量	460.69
包装储存	-20°C, protect from light, stored under nitrogen 该产品在溶液状态不稳定，建议您现用现配，即刻使用。

产品详情	Lexacalcitol (KH1060) 是一种维生素 D 类似物，是细胞生长和免疫反应的有效调节剂。Lexacalcitol 可用于移植排斥反应、银屑病、癌症和自身免疫性疾病的研究。
生物活性	Lexacalcitol (KH1060), a vitamin D analog, is a potent regulator of cell growth and immune responses. Lexacalcitol can be used for the research of graft rejection, psoriasis, cancer and auto-immune diseases.
性状	Solid
体外研究(In Vitro)	Lexacalcitol inhibits cell proliferation by 50% at 10 M (14,000 times more active than la,25(OH)2D3) in human histiocytic lymphoma cell line U 937. Lexacalcitol inhibits interleukin-1-induced mouse thymocyte proliferation by 50% at 3×10 M , allogeneic stimulation of mouse spleen lymphocytes at 5×10 M. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Lexacalcitol (0.5 mg/kg/2 days; i.p.) in combination with cyclosporin A (CyA) can prevent autoimmune destruction of syngeneic islet grafts in spontaneously diabetic NOD recipients. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, protect from light, stored under nitrogen 该产品在溶液状态不稳定，建议您现用现配，即刻使用。
参考文献	[1]. L Binderup, et al. 20-epi-vitamin D3 analogues: a novel class of potent regulators of cell growth and immune responses. Biochem Pharmacol. 1991 Sep 27;42(8):1569-75. [2]. C Gysemans, et al. A combination of KH1060, a vitamin D(3) analogue, and cyclosporin prevents early graft failure and prolongs graft survival of xenogeneic islets in nonobese diabetic mice. Transplant Proc. 2001 May;33(3):2365.

溶解度数据	In Vitro: DMSO : 100 mg/mL (217.07 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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