ZAP-180013 是一种 ZAP-70 抑制剂，IC₅₀ 为 1.8 μM。ZAP-180013 抑制 ZAP-70 SH2 结构域与基于免疫受体酪氨酸的激活基序 (ITAM) 的相互作用。

ZAP-180013 is a zeta-chain-associated protein kinase 70 (ZAP-70) inhibitor with an IC 50 of 1.8 μM. ZAP-180013 inhibits the interaction of ZAP-70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs).

Solid

IC50: 1.8 μM (ZAP-70)

ZAP-70 is a critical molecule in the transduction of T cell antigen receptor signaling and the activation of T cells. Upon activation of the T cell antigen receptor, ZAP-70 is recruited to the intracellular ζ-chains of the T cell receptor, where ZAP-70 is activated and colocalized with its substrates. Inhibitors of ZAP-70 could potentially function as treatments for autoimmune diseases or organ transplantation. ZAP-180013 disrupts the interaction between ZAP-70 and the T cell antigen receptor. The IC50s in both FP and TR-FRET assays for ZAP-180013 are 9.6 μM and 16.841 μM, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；In solvent -80°C 6 months

[1]. Patrick R Visperas, et al. Identification of Inhibitors of the Association of ZAP-70 With the T Cell Receptor by High-Throughput Screen. SLAS Discov. 2017 Mar;22(3):324-331.

In Vitro: DMSO : 250 mg/mL (550.26 mM; Need ultrasonic)配制储备液