BT-13|924537-98-4|-陌孚医药/Medlife

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BT-13

目录号: PL10957 纯度: ≥99%

CAS No. :924537-98-4

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中文名称	BT-13
英文名称	BT-13
英文别名	BT13;N,N-Diethyl-3-(4-(4-fluoro-2-(trifluoromethyl)benzoyl)piperazin-1-yl)-4-methoxybenzenesulfonamide;N,N-diethyl-3-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]-4-methoxybenzenesulfonamide;BT 13;BB168381;N,N-Diethyl-3-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]-1-piperazinyl]-4-methoxybenzenesulfonamide (ACI);BT-13
Cas No.	924537-98-4
分子式	C₂₃H₂₇F₄N₃O₄S
分子量	517.54
包装储存	Powder -20°C 3 years；In solvent -80°C 6 months

产品详情	BT-13 是有效的、胶质细胞源性神经营养因子 (GDNF) 受体 RET 的选择性激动剂 (独立于 GDNF 配体发挥作用)，促进体外感觉神经元神经突生长，减轻大鼠神经病变的发生。
生物活性	BT-13 is a potent and selective glial cell line-derived neurotrophic factor (GDNF) receptor RET agonist independently of GFLs, promoting neurite growth from sensory neurons in vitro and attenuates experimental neuropathy in the Rat.
性状	Solid
IC50 & Target[1][2]	GDNF receptor RET.
体外研究(In Vitro)	BT-13 stimulates phosphorylation of RET, as well as RET-dependent intracellular signaling, but activated neither NGF receptor TrkA nor BDNF receptor TrkB nor intracellular signaling in the absence of RET. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	BT-13 (20 and 25mg/kg in rats induced by ligation of left L5 and L6 spinal nerves) has a slight antinociceptive/antihyperalgesic effect and protected DRG neurons in rats with surgery-induced neuropathy. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；In solvent -80°C 6 months
参考文献	[1]. Sidorova YA, et al. A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat. Front Pharmacol. 2017 Jun 21;8:365.

溶解度数据	In Vitro: DMSO : 25 mg/mL (48.31 mM; Need ultrasonic)配制储备液

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