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2-Methylthio-AMP

(Synonyms: 2-MeSAMP; 2-Methylthioadenosine 5′-monophosphate; 2-Methylthioadenosine 5′-phosphate)

目录号: PL08695 纯度: ≥99%

2-Methylthio-AMP (2-MeSAMP) 是一种选择性和直接的 P2Y12 拮抗剂。2-Methylthio-AMP 是 ADP 依赖性血小板聚集的抑制剂

CAS No. :22140-20-1

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中文名称	2-Methylthio-AMP
中文别名	5-磷酸-2-甲基硫代腺苷酸
英文名称	2-Methylthio-AMP
英文别名	5'-Adenylic acid,2-(methylthio)-;2- METHYLTHIOADENOSINE- 5'- O- MONOPHOSPHATE ( 2-MES-5'-AMP );2-METHYLTHIOADENOSINE 5-MONOPHOSPHATE;2,6,2',6'-TETRAMETHYLAZOBENZENE NN'-DIOXIDE---CRYSTALLINE;2-mesamp;2-MeSAMP,2-Methylthio-AMP hydrate triethylammonium salt;2-methylthioadenosine 5'-monophosphate triethylammonium salt hydrate;2-methylthioadenosine-5'-monophosphate;2-Methylthio-AMP
Cas No.	22140-20-1
分子式	C₁₁H₁₆N₅O₇PS
分子量	393.31
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	2-Methylthio-AMP (2-MeSAMP) 是一种选择性和直接的 P2Y₁₂ 拮抗剂。2-Methylthio-AMP 是 ADP 依赖性血小板聚集的抑制剂
生物活性	2-Methylthio-AMP (2-MeSAMP) is a selective and direct P2Y 12 antagonist. 2-Methylthio-AMP is an inhibitor of ADP-dependent platelet aggregation.
性状	Solid
IC50 & Target[1][2]	P2Y12
体外研究(In Vitro)	2-Methylthio-AMP (2-MeSAMP) inhibits agonist-mediated αIIbβ3 activation in platelets. 2-methylthio-AMP (50 μM; for 5 minutes) does not significantly inhibit thrombin, PAR1-AP, PAR4-AP, or ADP-mediated platelet Ca mobilization. 2-methylthio-AMP fails to inhibit Ca mobilization in P2Y12-deficient mouse platelets and does not raise cAMP or induce vasodilator-stimulated phosphoprotein phosphorylation in wild-type platelets. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. John H Cleator, et al. Racial differences in resistance to P2Y12 receptor antagonists in type 2 diabetic subjects. J Pharmacol Exp Ther. 2014 Oct;351(1):33-43. [2]. Bernhard H Rauch, et al. Regulation of functionally active P2Y12 ADP receptors by thrombin in human smooth muscle cells and the presence of P2Y12 in carotid artery lesions. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2434-42.

溶解度数据	In Vitro: DMSO : 100 mg/mL (254.25 mM; Need ultrasonic)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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