Cangrelor tetrasodium|163706-36-3|(AR-C69931MX tetrasodium)-陌孚医药/Medlife

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Cangrelor tetrasodium (Synonyms: AR-C69931MX tetrasodium)

目录号: PL08700 纯度: ≥99%

CAS No. :163706-36-3

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中文名称	Cangrelor tetrasodium
中文别名	N-(4-硝基苯基)甲酰胺;坎格雷洛四钠;坎格雷洛四钠盐;坎格雷诺;坎格瑞洛四钠;坎格瑞洛
英文名称	Cangrelor tetrasodium
英文别名	tetrasodium 5'-O-[({[dichloro(phosphonato)methyl]phosphinato}oxy)phosphinato]-N-[2-(methylsulfanyl)ethyl]-2-[(3,3,3-trifluoropropyl)sulfanyl]adenosine;tetrasodium,[dichloro(phosphonato)methyl]-[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(2-methylsulfanylethylamino)-2-(3,3,3-trifluoropropylsulfanyl)purin-9-yl]oxolan-2-yl]methoxy-oxidophosphoryl]oxyphosphinate;AR-C69931 tetrasodium salt;AR-C69931MX tetrasodium salt;N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-, anhydride with P,P′-(dichloromethylene)bis[phosphonic acid]-5′-Adenylic acid tetrasodium salt;AR-C 69931MX;angrelor tetrasodium;cangrelor tetrasodium;Cangrelor tetrasodium
Cas No.	163706-36-3
分子式	C₁₇H₂₁N₅O₁₂F₃P₃S₂Cl₂-₄^.₄[Na+]
分子量	864.29
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情

Cangrelor tetrasodium 是一种三磷酸腺苷类似物，是一种可逆的、选择性的血小板 P2Y12 拮抗剂，具有迅速有效的抗血小板作用。Cangrelor tetrasodium 直接阻断腺苷二磷酸 (ADP) 诱导的血小板活化和聚集。Cangrelor tetrasodium 也是一种非特异性的 GPR17 拮抗剂。

生物活性

Cangrelor tetrasodium, an adenosine triphosphate analogue, is a reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor tetrasodium directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor tetrasodium is also a nonspecific GPR17 antagonist.

性状

Solid

IC50 & Target[1][2]

P2Y12 Receptor

体外研究(In Vitro)

Cangrelor tetrasodium is the only potent intravenous direct and specific adenosine diphosphate (ADP) P2Y12 receptor antagonist.
Cangrelor tetrasodium has pKb of 8.6-9.2 for hP2Y12 receptor. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Cangrelor tetrasodium (10 mg/kg) not only significantly decreases BLM-induced release of inflammatory cytokines (PF4, CD40 L and MPO), but also decreases the increment of platelets, neutrophils and platelet-neutrophil aggregates in the fibrotic lung and in the peripheral blood of BLM-treated mice. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

ClinicalTrial

参考文献

[1]. Bhattad VB, , et al. Intravenous cangrelor as a peri-procedural bridge with applied uses in ischemic events. Ann Transl Med. 2019;7(17):408.
[2]. Zhan T, Wei T, et al. Cangrelor alleviates bleomycin-induced pulmonary fibrosis by inhibiting platelet activation in mice. Mol Immunol. 2020;120:83-92.

溶解度数据	In Vitro: H₂O : 125 mg/mL (144.63 mM; Need ultrasonic)DMSO : 12.5 mg/mL (14.46 mM; ultrasonic and warming and heat to 80°C)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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