A-317491 sodium salt hydrate||-陌孚医药/Medlife

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A-317491 sodium salt hydrate

目录号: PL08669 纯度: ≥99%

商品编号	规格	价格	会员价
PL08669-5mg	5mg	¥1525.00	请登录
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PL08669-50mg	50mg	¥7682.00	请登录
PL08669-100mg	100mg	询价	询价
PL08669-200mg	200mg	询价	询价
PL08669-10mM*1mLinWater	10mM*1mLinWater	¥2034.00	请登录

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中文名称	A-317491 sodium salt hydrate
英文名称	A-317491 sodium salt hydrate
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	A-317491 sodium salt hydrate 是一种有效，选择性和非核苷酸的 P2X₃ 和 P2X_2/3 受体的拮抗剂，对 hP2X₃，rP2X₃，hP2X_2/3 和 rP2X_2/3 的 K_i 值分别为 22，22，9 和 92 nM。A-317491 sodium salt hydrate 对其他 P2 受体和神经递质受体，离子通道以及酶具有高度选择性 (IC50>10 μM)。A-317491 sodium salt hydrate 通过阻断 P2X₃ 和 P2X_2/3 受体介导的钙通量减轻炎性和神经性疼痛。
生物活性	A-317491 sodium salt hydrate is a potent, selective and non-nucleotide antagonist of P2X 3 and P2X 2/3 receptors, with K i s of 22, 22, 9, and 92 nM for hP2X 3 , rP2X 3 , hP2X 2/3 , and rP2X 2/3 , respectively. A-317491 sodium salt hydrate is highly selective (IC50>10 μM) over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes. A-317491 sodium salt hydrate reduces inflammatory and neuropathic pain by blocking P2X 3 and P2X 2/3 receptor-mediated calcium flux.
性状	Solid
IC50 & Target[1][2]	P2X3 Receptor
体外研究(In Vitro)	A-317491 potently blocks recombinant human and rat P2X3 and P2X2/3 receptor-mediated calcium flux (Ki=22-92 nM) . A-317491 (1 nM-10 μM) produces a concentration-dependent block of dorsal root ganglion (DRG) currents with an IC50 of 15 nM. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	A-317491 (0.1-30 mg/kg; a single s.c.) dose-dependently reverses inflammatory mechanical hyperalgesia in rats. A-317491 (3-30 mg/kg; a single .v.) exhibits the plasma half-life (7.38 h), clearance rate (1.83 L/h/kg), and volume of distribution (0.17 L/kg). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Jarvis MF, et, al. A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17179-84. [2]. Wu G, et, al. A-317491, a selective P2X3/P2X2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats. Eur J Pharmacol. 2004 Nov 3;504(1-2):45-53.

溶解度数据	In Vitro: H₂O : 100 mg/mL (164.86 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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