6-Mercaptopurine hydrate|6112-76-1|-陌孚医药/Medlife

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6-Mercaptopurine hydrate

目录号: PL07947 纯度: ≥98.0%

6-Mercaptopurine hydrate (Mercaptopurine hydrate; 6-MP hydrate) 是一种嘌呤类似物，是内源性嘌呤的拮抗剂且已被广泛用作抗白血病药物和免疫抑制药物。

CAS No. :6112-76-1

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中文名称	6-Mercaptopurine hydrate
中文别名	6-巯(基)嘌呤一水合物;6-疏基嘌呤;6-巯基单酯;6-巯基嘌呤单水合物;嘌呤-6-硫醇;6-巯基嘌呤(一水合物);6-巯基嘌呤一水物;巯嘌呤;6-羟基嘌呤单水合物;6-巯基嘌呤,一水合物;6-巯基嘌呤水合物;6-Mercaptopurine Monohydrate 6-巯基嘌呤水合物;6-巯基嘌呤;巯基嘌呤;巯基嘌呤 USP标准品;巯基嘌呤杂质标准;6-硫代嘌呤;6-嘌呤硫醇;乐疾宁;巯嘌呤,乐疾宁,6-巯嘌呤;湖北扬信现货供应巯嘌呤杂质 ABCDE;6-巯基嘌呤一水合物;6-巯基嘌呤一水合物
英文名称	6-Mercaptopurine hydrate
英文别名	6-Mercaptopurine monohydrate;6-MERCAPTO PURINE;1,7-dihydro-6h-purin-6-thion,monohydrat;1,7-dihydro-6h-purine-6-thionemonohydrate;1,7-dihydro-6h-purine-6-thionmonohydrate;6h-purin-6-thion,monohydrat;6-merkaptopurin,monohydrat;purin-6-thiol,monohydrat;PURINE-6-THIOL, MONOHYDRATE;MERCALEUKIN MONOHYDRATE;MERCAPTOPURINE, MONOHYDRATE;MERCAPTOPURINE MONOHYDRATE, 6-;MERCAPTOPURINE;LEUKERIN MONOHYDRATE;6-PURINETHIOL MONOHYDRATE;6-thiohypoxanthine monohydrate;6-MERCAPTOPURINE HYDRATE;6-MP;6-Mercaptopurine Mon;MERCAPTOPURINE MONOHYDRATE, 6-(RG);6MP H2O;6MP MONOHYDRATE;purin-6-thiol,monohydrate;Mercaptopurine Monohydrate;Mercaptopurine hydrate;6,7-dihydro-3H-purine-6-thione hydrate;6H-Purine-6-thione, 1,7-dihydro-, monohydrate;Purine-6-thiol monohydrate;1,7-Dihydro-6H-purine-6-thione monohydrate;6-Mercaptopurine (6-MP) Monohydrate;C5H4N4S.H2O;Purin-6-thiol, monohydrat [Czech];6-Merkaptopurin, monohydrat [Czech];6H-Purin-6-thion, m;6-Mercaptopurine;6-Purinethiol monohydrate;6-Thiohypoxanthine monohydrate
Cas No.	6112-76-1
分子式	C₅H₆N₄Os
分子量	170.19
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

6-Mercaptopurine hydrate (Mercaptopurine hydrate; 6-MP hydrate) 是一种嘌呤类似物，是内源性嘌呤的拮抗剂且已被广泛用作抗白血病药物和免疫抑制药物。

生物活性

6-Mercaptopurine hydrate (Mercaptopurine hydrate; 6-MP hydrate) is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug.

性状

Solid

IC50 & Target[1][2]

endogenous purines

体外研究(In Vitro)

6-Mercaptopurine hydrate (Mercaptopurine hydrate; 6-MP hydrate) induces NR4A3 transcriptional activity 1.6- to 11-fold (P<0.01) in a dose-responsive manner. It is found that 6-Mercaptopurine hydrate leads to a dose-dependent increase in NR4A3 protein levels.
6-Mercaptopurine hydrate treatment increases cell surface GLUT4 in both basal cells 1.8- to 3.6-fold (P<0.01) and insulin-stimulated cells 2.9- to 4.4-fold (P<0.01) over that in controls. It is also found that 6-Mercaptopurine hydrate increases phospho-AS160 significantly in a dose-responsive manner under both basal and insulin-stimulated conditions. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

In the fetal telencephalons of the 6-Mercaptopurine hydrate (6-MP)-treated group, the S phase cell population increases at 36 and 48 h and returns to the control level at 72 h after treatment. The G2/M phase cell population begins to increase at 24 h, peaks at 36 h, decreases at 48 h, and finally returnes to the control level at 72 h. On the other hand, the sub-G1 phase cell population (apoptotic cells) begins to increase at 36 h, peaks at 48 h, and then decreases at 72 h. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Sahasranaman S, et al. Clinical pharmacology and pharmacogenetics of thiopurines. Eur J Clin Pharmacol. 2008 Aug;64(8):753-67.
[2]. Liu Q, et al. 6-Mercaptopurine augments glucose transport activity in skeletal muscle cells in part via a mechanism dependent upon orphan nuclear receptor NR4A3. Am J Physiol Endocrinol Metab. 2013 Nov 1;305(9):E1081-92.

溶解度数据	In Vitro: DMSO : 50 mg/mL (293.79 mM; Need ultrasonic)H₂O : < 0.1 mg/mL (insoluble)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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