Substance P(1-7) TFA|2828433-22-1|-陌孚医药/Medlife

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Substance P(1-7) TFA

目录号: PL07724 纯度: ≥99%

CAS No. :2828433-22-1

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中文名称	Substance P(1-7) TFA
中文别名	(S)-2-((S)-5-氨基-2-((S)-5-氨基-2-((S)-1-((S)-6-氨基-2-((S)-1-((S)-2-氨基-5-胍基戊酰基)吡咯烷-2-羧酰胺基)己酰基)吡咯烷-2-羧酰胺基)-5-氧代戊酰氨基)-5-氧代戊酰氨基)-3-苯基丙酸三氟乙酸盐
英文名称	Substance P(1-7) TFA
Cas No.	2828433-22-1
分子式	C₄₃H₆₆F₃N₁₃O₁₂
分子量	1014.06
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	Substance P(1-7) TFA 是神经肽 P 物质 (SP) 的片段。Substance P(1-7) TFA 可对孤束核产生抑制和缓和作用。
生物活性	Substance P(1-7) TFA is a fragment of the neuropeptide, substance P (SP). Substance P(1-7) TFA gives depressor and bradycardic effects when applied to the nucleus tractus solitarius.
性状	Solid
体内研究(In Vivo)	Substance P(1-7) is found to act as a very potent antagonist against the SP-induced responses and is formed locally in the nigra after SP injection. It is proposed that Substance P(1-7) is an endogenous modulator of SP actions. Injection of low doses of Substance P(1-7) (1.0-4.0 pM simultaneously with SP or SP(5-11) (0.1 nM), reduce aversive behaviours induced by SP or SP(5- 11) significantly. These results indicate that SP(1-7) formed endogenously could modulate the actions of SP or SP(5-11) in the spinal cord. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	RPKPQQF
Sequence	Arg-Pro-Lys-Pro-Gln-Gln-Phe
参考文献	[1]. Herrera-Marschitz M, et al. The substance P(1-7) fragment is a potent modulator of substance P actions in the brain. Brain Res. 1990 Jun 25;521(1-2):316-20. [2]. Sakurada T, et al. Substance P(1-7) antagonizes substance P-induced aversive behaviour in mice. Neurosci Lett. 1988 Dec 19;95(1-3):281-5.

溶解度数据	In Vitro: H₂O : 50 mg/mL (49.31 mM; Need ultrasonic)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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