Vapreotide|103222-11-3|(伐普肽; RC160; BMY 41606)-陌孚医药/Medlife

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Vapreotide (Synonyms: 伐普肽; RC160; BMY 41606)

目录号: PL07718 纯度: ≥98%

CAS No. :103222-11-3

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中文名称	Vapreotide
中文别名	伐普肽;醋酸伐普肽;N-乙酰-D-谷氨酸
英文名称	Vapreotide
英文别名	Vapreotide;RC 160;RC-160(VAPREOTIDE);Vapreotide Acetate;BMY 41606;BMY-41606;D-PHE-CYS-TYR-D-TRP-LYS-VAL-CYS-TRP-NH2;FCYWKVCW-NH2;H-D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH2;Octastatin;RC-160;Vapreotide, RC-160;D-Phe-L-Cys(1)-L-Tyr-D-Trp-L-Lys-L-Val-L-Cys(1)-L-Trp-NH2;D-Phe-Cys-Trp-D-Trp-Lys-Val-Cys-Trp-CONH2(disulfide Cys2-Cys7);D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH2 (Disulfide bridge Cys2-Cys7)
Cas No.	103222-11-3
分子式	C₅₇H₇₀N₁₂O₉S₂
分子量	1131.37
包装储存	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year

产品详情

Vapreotide 是神经激肽-1 (NK1) 受体拮抗剂，其 IC₅₀ 值为 330 nM。

生物活性

Vapreotide is a neurokinin-1 (NK1) receptor antagonist, with an IC 50 of 330 nM.

性状

Solid

IC50 & Target[1][2]

NK1

体外研究(In Vitro)

Vapreotide attenuates the effect of SP on calcium release in a concentration-dependent manner. The concentration required for Vapreotide to completely inhibit the effect of SP is about 100 times higher than that required for the NK1R antagonist aprepitant. The effect of Vapreotide on cell proliferation is mediated primarily by SSTR2. In order to further establish the NK1R antagonist effect of Vapreotide, U373MG cells are pretreated with SSTR2 selective antagonist CYN followed by incubation with Vapreotide and SP stimulation. The results show that pretreatment with CYN does not reverse the inhibitory effect of Vapreotide on SP-stimulated IL-8 mRNA expression. Vapreotide reduces HIV-1 replication in MDM as indicated by limited HIV gag mRNA expression compared to control MDM. In addition, SP treatment (10 μM) reverses Vapreotide inhibition of HIV-1 replication in MDM. This observ

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year

ClinicalTrial

SequenceShortening

FCYWKVCW-NH2 (Disulfide bridge: Cys2-Cys7)

Sequence

Phe-Cys-Tyr-Trp-Lys-Val-Cys-Trp-NH2 (Disulfide bridge: Cys2-Cys7)

参考文献

[1]. Spitsin S et al. Analog of somatostatin vapreotide exhibits biological effects in vitro via interaction with neurokinin-1 receptor. Neuroimmunomodulation. 2013;20(5):247-55.

溶解度数据	In Vitro: H₂O : 100 mg/mL (88.39 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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