RMC-6272|2382769-46-0|(RM-006)-陌孚医药/Medlife

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RMC-6272 (Synonyms: RM-006)

目录号: PL07555 纯度: ≥95%

CAS No. :2382769-46-0

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中文名称	RMC-6272
中文别名	RMC-6272
英文名称	RMC-6272
英文别名	RM-006;RMC-6272
Cas No.	2382769-46-0
分子式	C₉₅H₁₄₁FN₆O₂₇S
分子量	1850.22
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	RMC-6272 (RM-006) 是一种双空间的，选择性的 mTORC1 抑制剂，对 mTORC1 的抑制作用比 mTORC2 强且选择性 >10 倍。与雷帕霉素相比，RMC-6272 对 mTORC1 的抑制作用增强，并在 TSC2 阴性肿瘤中诱导更多的细胞死亡。
生物活性	RMC-6272 (RM-006) is a bi-steric mTORC1-selective inhibitor. RMC-6272 exhibits potent and selective (> 10-fold) inhibition of mTORC1 over mTORC2. RMC-6272 shows improved inhibition of mTORC1 in comparison to Rapamycin, and induces more cell death in TSC2 null tumors.
性状	Solid
体外研究(In Vitro)	RMC-6272 shows more effective growth inhibition in multiple TSC1 or TSC2 mutant tumor cell lines compared to Rapamycin. RMC-6272 causes a more profound growth inhibition in the TSC1 or TSC2 mutant cells than the wild type cells. RMC-6272 at ~1 nM shows near complete inhibition of p4E-BP1, while inhibition of pS6 levels is similar for Rapamycin and RM compounds. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	RMC-6272 markedly reduces kidney tumor burden in Tsc2 A/J mice after four weeks of treatment. Tumor regrowth is assessed two months after treatment cessation, tumor burden is significantly reduced in the RMC-6272 group as compared to the Rapamycin and MLN0128 groups. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Heng Du, et al. Bi-steric mTORC1-selective inhibitors demonstrate improved potency and efficacy in tumors with mTORC1 hyperactivation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 1

溶解度数据	In Vitro: DMSO : 25 mg/mL (13.51 mM; ultrasonic and warming and heat to 60°C)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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