ML-00253764 hydrochloride|1706524-94-8|-陌孚医药/Medlife

您当前的位置：

ML-00253764 hydrochloride

目录号: PL07069 纯度: ≥98%

CAS No. :1706524-94-8

商品编号	规格	价格	会员价
PL07069-5mg	5mg	¥2169.00	请登录
PL07069-10mg	10mg	¥3696.00	请登录
PL07069-25mg	25mg	¥8036.00	请登录
PL07069-50mg	50mg	¥13661.00	请登录
PL07069-100mg	100mg	¥23305.00	请登录
PL07069-200mg	200mg	询价	询价
PL07069-500mg	500mg	询价	询价

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	ML-00253764 hydrochloride
中文别名	化合物 T12072
英文名称	ML-00253764 hydrochloride
英文别名	2-[2-[2-(5-Bromo-2-methoxyphenyl)ethyl]-3-fluorophenyl]-4,5-dihydro-2-1H-imidazole hydrochloride;ML-00253764 hydrochloride
Cas No.	1706524-94-8
分子式	C₁₈H₁₉BrClFN₂O
分子量	413.71
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	ML-00253764 是一种非肽类黑皮质素受体 4 (MC4R) 拮抗剂，其 K_i 和 IC₅₀ 值分别为 0.16 µM 和 0.103 µM。脑渗透剂。
生物活性	ML-00253764 hydrochloride is a brain penetrant nonpeptidic melanocortin receptor 4 (MC4R) antagonist with a K i and IC 50 of 0.16 μM and 0.103 μM, respectively.
性状	Solid
IC50 & Target[1][2]	Ki: 0.16 μM IC50: 0.103 μM (melanocortin receptor 4)
体外研究(In Vitro)	ML-00253764 displaces NDP-α-MSH binding with a mean IC50 of 0.32 μM, 0.81 μM and 2.12 μM for hMC4-R, hMC3-R and hMC5-R, respectively. ML-00253764 (100 μM) decreases cAMP production induced by [NLE4,D-Phe7]-α-melanocyte stimulating hormone ([NDP]-α-MSH) by 20% in MC4R-expressing HEK293 cell membranes, but has no effect on cAMP levels in MC3R- or MC5R-expressing membranes. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	ML-00253764 (subcutaneous injection; 3, 10, or 30 mg/kg; once daily) shows protection against tumor-induced body weight loss upon chronic, peripheral dosing in CT-26 tumor bearing BALB/c mice. ML-00253764 dissolves in polyethylene glycol 200/saline (1:10) in a volume of 10 mL/kg (For reference only). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Vos TJ, et al. Identification of 2-[2-[2-(5-bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model. J Me

溶解度数据	In Vitro: DMSO : 12.5 mg/mL (30.21 mM; ultrasonic and warming and heat to 60°C)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation