SNT-207707|1064662-40-3|-陌孚医药/Medlife

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SNT-207707

目录号: PL07066 纯度: ≥99%

CAS No. :1064662-40-3

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中文名称	SNT-207707
英文名称	SNT-207707
英文别名	Imidazo[1,2-a]pyridine-6-carboxamide, 2-(4-cyanophenyl)-N,N-bis(3-methylbutyl)-3-[3-(1-pyrrolidinyl)propyl]-, hydrochloride (1:1);2-(4-Cyanophenyl)-N,N-bis(3-methylbutyl)-3-[3-(1-pyrrolidinyl)pro pyl]imidazo[1,2-a]pyridine-6-carboxamide hydrochloride (1:1);Imidazo[1,2-a]pyridine-6-carboxamide, 2-(4-cyanophenyl)-N,N-bis(3-methylbutyl)-3-[3-(1-pyrrolidinyl)propyl]-, hydrochloride (;SNT-207707
Cas No.	1064662-40-3
分子式	C₃₂H₄₃N₅O^.HCl
分子量	550.18
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	SNT-207707是一种有效，选择性，有口服活性的黑素皮质素受体 (melanocortin MC-4) 拮抗剂，IC₅₀ 值为8 nM (结合) 和5 nM (功能)。
生物活性	SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC 50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor.
性状	Solid
IC50 & Target[1][2]	IC50: 8 nM (binding MC-4), 5 nM (function MC-4)
体外研究(In Vitro)	SNT-207707 binds to the MC-4 receptor with an affinity of 8 nM and shows a more than 200-fold selectivity vs. MC-3 and MC-5. SNT207858 is a 22 nM MC-4 antagonist with a 170-fold selectivity vs. MC-3 and a 40-fold selectivity versus MC-5. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Single subcutaneous injection of 20 mg/kg of SNT-207707 distinctly increases food intake of the mice. Once daily oral administration of both compounds SNT207858 and SNT-207707 starting the day after tumor implantation significantly reduces the tumor induced weight loss. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Weyermann P, et al. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774.

溶解度数据	In Vitro: DMSO : ≥ 250 mg/mL (454.40 mM)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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