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Propiverine hydrochloride

(Synonyms: 盐酸丙哌维林)

目录号: PL06884 纯度: ≥98%

Propiverine hydrochloride 是具有钙拮抗和抗胆碱能特性的膀胱痉挛剂。Propiverine hydrochloride 可用于研究膀胱过度活动和尿失禁。

CAS No. :54556-98-8

商品编号	规格	价格	会员价
PL06884-25mg	25mg	¥243.00	请登录
PL06884-50mg	50mg	¥348.00	请登录
PL06884-100mg	100mg	¥524.00	请登录
PL06884-10mM*1mLinDMSO	10mM*1mLinDMSO	¥884.00	请登录
PL06884-1 mL x 10 mM (in DMSO)		¥135.00	请登录

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中文名称	Propiverine hydrochloride
中文别名	盐酸丙哌维林;1-甲基-4-哌啶基二苯基丙氧乙酸酯盐酸盐;盐酸丙哌唯林;盐酸丙哌维林标准品(JP);罗匹外宁
英文名称	Propiverine hydrochloride
英文别名	Propiverine hydrochloride;1-Methyl-4-piperidyl diphenylpropoxyacetate hydrochloride;(1-Methyl-3,4,5,6-tetrahydro-2H-pyridin-4-yl) 2,2-diphenyl-2-propoxy-acetate chloride;Propiverine Hydrochl;α,α-Diphenyl-α-propoxyacetic acid hydrochloride 1-methyl-4-piperidyl ester;α-Phenyl-α-propoxybenzeneacetic acid 1-methyl-4-piperidinyl ester hydrochloride;(1-Methylpiperidin-1-ium-4-yl) 2,2-diphenyl-2-propoxyacetate chloride
Cas No.	54556-98-8
分子式	C₂₃H₂₉NO₃^.HCl
分子量	403.95
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	Propiverine hydrochloride 是具有钙拮抗和抗胆碱能特性的膀胱痉挛剂。Propiverine hydrochloride 可用于研究膀胱过度活动和尿失禁。

产品详情

Propiverine hydrochloride 是具有钙拮抗和抗胆碱能特性的膀胱痉挛剂。Propiverine hydrochloride 可用于研究膀胱过度活动和尿失禁。

生物活性

Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence.

性状

Solid

体外研究(In Vitro)

Propiverine (10-3000 nM) inhibits the speci?c binding of [H]NMS, with Kis of 339, 193 and 497 nM in the bladder, submaxillary gland and heart of mice respectively. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Propiverine (0.5 mg/day; p.o. once daily for 2 weeks) significantly increases UBP and LPP during passive intravesical pressure elevation, and also increases plasma norepinephrine and epinephrine levelsin rats.
Propiverine (0.01-1 mg/kg; i.v.) decreases the UBP and totally suppresses the sneeze reflex at the dose of 1 mg/kg in vivo. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Kitta T, et, al. Effects of propiverine hydrochloride, an anticholinergic agent, on urethral continence mechanisms and plasma catecholamine concentration in rats. Int Urogynecol J. 2013 Apr; 24(4): 683-8.
[2]. Ito Y, et, al. Muscarinic Receptor Binding and Plasma Drug Concentration after the Oral Administration of Propiverine in Mice. Low Urin Tract Symptoms. 2010 Apr; 2(1):43-9.

溶解度数据	In Vitro: H₂O : 50 mg/mL (123.78 mM; Need ultrasonic)DMSO : 50 mg/mL (123.78 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Propiverine hydrochloride

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