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产品总数：60957
| 中文名称 |
DOPE
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|---|---|
| 中文别名 |
1,2-二油酰基-sn-丙三基-3-磷脂酰乙醇胺;1,2-二油锡甘油-3-磷酸乙醇胺;DOPE,二油酰基磷脂酰乙醇胺;二油酰基磷脂酰乙醇胺;1,2-二油酰-sn-甘油-3-磷酸乙醇胺;1,2-二油酰甘油-3-磷酸乙醇胺;二油酰基磷脂酰乙醇胺DOPE;2-氨乙基 (R)-2,3-二(2-油酰氧)丙基磷酸氢酯;1,2-二油酰-sn-甘油-3-磷酰乙醇胺;二油酰磷脂酰乙醇胺
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| 英文名称 |
DOPE
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| 英文别名 |
9-Octadecenoic acid(9Z)-,1,1'-[(1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl]ester;1, 2-dioleoyl-sn-glycero-3-phosphoethanolamine;1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE);9-Octadecenoic acid(9Z)-,1,1'-[(1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-etha...;COATSOME ME-8181 (DOPE);DOPE;1,2-dioleoyl-sn-glycero-3-phosphatidylethanolamine;1,2-dioleoyl-sn-glycero-3-phosphoethanoloamine;1,2-dioleoyl-sn-glycerol-3-phosphoethanolamine;1,2-di-O-oleoyl-sn-glycero-3-phosphatidylethanolamine;18:1 PE;3-SN-PHOSPHATIDYLETHANOLAMINE,1,2-DIDEOYL;DIOLEOYL PHOSPHATIDYL ETHANOLAMINE;Dioleoyl phosphoethanolamine;L-A-phosphatidylethanolamine dioleoyl;(9Z)-9-Octadecenoic acid (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester;1,2-Di(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine;L-β,γ-Dioleoyl-α-cephalin;2-Aminoethyl (R)-2,3-Bis(oleoyloxy)propyl Hydrogen Phosphate;1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine;110635;18:1(9Z));PE(18:1(9Z);3-sn-Phosphatidylethanolamine, 1,2-dideoyl;Dioleoyl phosphatidylethanolamine;PE(18:1(9Z)/18:1(9Z));1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; DOPE; PE(18:1(9Z)/18:1(9Z)); 110635;1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine;L-alpha-Phosphatidylethanolamine, Dioleoyl;DOPEA;Dioleoylphosphatidylethanolamine;PE 36:2;1,2-dioleoyl phosphatidylethanolamine;LipofectACE;1,2-Dioleoylphosphatidylethanolamine;DL-DOPE;Dioleoyl (glycerophospho)ethanolamine;1,2-Dioleoyl phosphatidyl ethanolamin;1,2-di-Olein 2-aminoethyl hydrogen phosphate;Epitope ID:136781;(Z)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dioleate;Ethanol, 2-ami
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| Cas No. |
4004-05-1
|
| 分子式 |
C41H78NO8P
|
| 分子量 |
744.03
|
| 包装储存 |
Powder -20°C 3 years；4°C 2 years
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| 产品详情 |
DOPE (dioleoylphosphatidylethanolamine) 是阳离子脂质体的中性辅助脂质 (helper lipid)，与阳离子磷脂结合，提高裸 siRNA 的转染效率。
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|---|---|
| 生物活性 |
DOPE (dioleoylphosphatidylethanolamine) is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA.
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| 性状 |
Solid
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| IC50 & Target[1][2] |
IC50: helper lipid for liposome
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| 体外研究(In Vitro) |
In this study, each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 molar percent).With the neutral lipid for the LNP is DOPE, LNP exerts knock-down (KD) effecton macrophages and DCs and Liposome-containing DOPE shows fusogenicity.LNP/siRNA significantly suppresses CD45 protein expression at an inhibition rate of 30% on macrophages and DCs but not on monocytes, neutrophils, plasmacytoid DCs, or B cells.LNP has the potential to be an efficient siRNA delivery system not only for murine but also for human macrophages and DCs. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
Powder -20°C 3 years；4°C 2 years
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| 参考文献 |
[1]. Uemura Y, et al. The efficiency of lipid nanoparticles with an original cationic lipid as a siRNA delivery system for macrophages and dendritic cells.Pharm Dev Technol. 2019 Mar;24(3):263-268.
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| 溶解度数据 |
In Vitro: DMSO : 50 mg/mL (67.20 mM; ultrasonic and warming and heat to 60°C)Ethanol : 40 mg/mL (53.76 mM; Need ultrasonic)配制储备液
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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