DOTAP chloride|132172-61-3|(1,2-Dioleoyl-3-trimethylammonium-propane chloride)-陌孚医药/Medlife

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DOTAP chloride (Synonyms: 1,2-Dioleoyl-3-trimethylammonium-propane chloride)

目录号: PL06718 纯度: ≥98.0%

CAS No. :132172-61-3

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PL06718-50mg	50mg	¥884.00	请登录
PL06718-100mg	100mg	¥1607.00	请登录
PL06718-250mg	250mg	¥3536.00	请登录
PL06718-500mg	500mg	¥6025.00	请登录
PL06718-1g	1g	询价	询价
PL06718-5g	5g	询价	询价
PL06718-10mM*1mLinDMSO	10mM*1mLinDMSO	¥980.00	请登录

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中文名称	DOTAP chloride
中文别名	(2,3-二油氧基丙基)三甲基氯化铵;1,2-二油酰-3-三甲基丙烷基氯化铵(DOTAP);1,2-三乙醇胺-3-三甲基丙烷;(2,3-二油酰基-丙基)-三甲胺;2-乙炔基-6-甲氧基萘
英文名称	DOTAP chloride
英文别名	N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE;1,2-Dioleoyl-3-trimethylammoniumpropane (chloride);1,2-Dioleoyl-3-triMethylaMMoniuM-propane, Chloride;2,3-di(octadec-9-enoyloxy)propyl-trimethylazanium;DOTAP;1,2-dioleoyl-3-trimethylammonium-propane chloride salt;2,3-dioleyloxypropyltrimethylammonium chloride;DOTAP chloride;N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride;DOTMA;Lipofectin;DOTAP CHLORIDE SALT;2,3-Bis(oleoyloxy)-N,N,N-trimethyl-1-propanaminium;TRIMETHYL[2,3-(DIOLEYLOXY)PROPYL]AMMONIUM CHLORIDE;N-[2,3-Di(oleoyloxy)propyl]-N,N,N-trimethylaminium;N-[2,3-Bis(oleoyloxy)propyl]-N,N-dimethylmethanaminium;1,2-Dioleoyl-3-trimethylammonium-propane chloride;dotap chloride;1,2-DIOLEOYL-3-TRIMETHYLAMMONIUM-PROPANE, CHLORIDE
Cas No.	132172-61-3
分子式	C₄₂H₈₀NO₄+
分子量	663.09
包装储存	-20°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

产品详情

DOTAP chloride 是一种高效的阳离子脂质 (cationic lipid)，用于瞬时或者稳定转染 DNA (质粒、bacmids) 和修饰核酸 (反义寡核苷酸)，并且可以不使用辅助脂质。

生物活性

DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid.

性状

<35°C Solid,>38°C Liquid

IC50 & Target[1][2]

IC50: Cationic Lipid

体外研究(In Vitro)

liposomes are reorganized by associating with DNA. The transfection efficiency of DOTAP liposomes is mainly influenced by lipid composition and cell type, but not by size or zeta potential.
has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

ClinicalTrial

参考文献

[1]. Kim BK, et al. DOTAP/DOPE ratio and cell type determine transfection efficiency with DOTAP-liposomes.Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):1996-2001.

溶解度数据	In Vitro: Ethanol : 130 mg/mL (186.10 mM; Need ultrasonic)DMSO : 25 mg/mL (35.79 mM; ultrasonic and warming and heat to 60°C)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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