Furaprofen (R803) 是一种有效的 HCV 复制抑制剂。作用于 HCV 基因型 1a 和 1b 复制子时 EC₅₀ 约为 30 nM，作用于基因型 2a 复制子时 EC₅₀ 约为 1000 nM。

Furaprofen (R803) is an effective HCV replication inhibitor. Furaprofen (R803) is substantially more potent against genotype 1a and 1b replicons (EC 50 , ~30 nM) than against the genotype 2a replicon (EC 50 , ~1,000 nM).

Solid

EC50: ~30 nM (HCV genotype 1a and 1b replicons), ~1000 nM (HCV genotype 2a replicon)

Furaprofen (R803) is potent and highly specific for HCV replication. The antiviral activity of Furaprofen has been determined by a reporter replicon assay with multiple repeats to be 29.88±8.05 nM, an ~3-fold improvement over the activity of the parent compound, R706. The potency of Furaprofen against the replicon is also confirmed by both Western blotting and TaqMan RT-PCR to be about 37 nM and 54.67±4.11 nM, respectively. To assess the general effect of Furaprofen on cell proliferation, a panel of primary cells and transformed human cell lines are treated with increasing doses of Furaprofen for 48 h, and the effect on cell proliferation is measured by an MTS-based cell viability assay. The the concentration that caused a 50% reduction in cell numbers in the absence of virus infection (CC50) of Furaprofen is found to range from 2 μM to ≥10 μM, depending on the cel

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Huang P, et al. Discovery and characterization of substituted diphenyl heterocyclic compounds as potent and selective inhibitors of hepatitis C virus replication. Antimicrob Agents Chemother. 2008 Apr;52(4):1419-29.

In Vitro: DMSO : 250 mg/mL (938.83 mM; Need ultrasonic)配制储备液