Onartuzumab|1133766-06-9|(MetMAb)-陌孚医药/Medlife

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Onartuzumab (Synonyms: MetMAb)

目录号: PL06069 纯度: ≥99%

CAS No. :1133766-06-9

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PL06069-5mg	5mg	¥22501.00	请登录
PL06069-10mg	10mg	询价	询价
PL06069-50mg	50mg	询价	询价

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中文名称	Onartuzumab
中文别名	ONARTUZUMAB ( 奥那妥组单抗 );奥那妥组单抗
英文名称	Onartuzumab
英文别名	Onartuzumab
Cas No.	1133766-06-9
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情

Onartuzumab (MetMAb) 是一种人源化亲和成熟的单价单克隆抗体，抑制受体酪氨酸激酶 MET。Onartuzumab 可有效抑制 HGF 结合、受体磷酸化和信号转导。Onartuzumab 具有抗体样药代动力学和抗肿瘤活性。

生物活性

Onartuzumab (MetMAb) is a unique, humanized and affinity-matured monovalent (one-armed) monoclonal antibody against the MET receptor. Onartuzumab potently inhibits HGF binding and receptor phosphorylation and signaling. Onartuzumab has antibody-like pharmacokinetics and antitumor activity.

性状

Liquid

体外研究(In Vitro)

Onartuzumab acts specifically by blocking HGF α-chain (but not β-chain) binding to MET.
Onartuzumab blocks HGF binding to human c-Met with an inhibitory concentration (IC)50 of 1.8 nM and inhibits the subsequent induction of c-Met auto-phosphorylation and cell proliferation in many cancer cell lines. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Onartuzumab (30 mg/kg, IP, twice a week for 2 mouth) suppresses tumor growth. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Human HGF-transgenic SCID mice implanted with BxPC3 tumor

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

ClinicalTrial

参考文献

[1]. Merchant M, et al. Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):E2987-96.
[2]. Prell RA, et al. Placental and Fetal Effects of Onartuzumab, a Met/HGF Signaling Antagonist, When Administered to Pregnant Cynomolgus Monkeys. Toxicol Sci. 2018 Sep 1;165(1):186-197.

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