Emibetuzumab|1365287-97-3|(LY2875358)-陌孚医药/Medlife

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Emibetuzumab (Synonyms: LY2875358)

目录号: PL06053

CAS No. :1365287-97-3

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PL06053-50mg	50mg	询价	询价
PL06053-100mg	100mg	询价	询价

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中文名称	Emibetuzumab
英文名称	Emibetuzumab
英文别名	Emibetuzumab
Cas No.	1365287-97-3
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情

Emibetuzumab (LY2875358) 是一种人源化二价 MET 抗体 (IgG4 型)。Emibetuzumab 具有较高的中和与内化活性，能有效抑制 HGF 依赖性和非依赖性 MET 通路的激活和肿瘤生长。Emibetuzumab 可用于癌症的研究。

生物活性

Emibetuzumab (LY2875358) is a humanized bivalent MET antibody (IgG4 type). Emibetuzumab shows high neutralization and internalization activities, resulting in inhibition of both HGF-dependent and HGF-independent MET pathway activation and tumor growth. Emibetuzumab can be used in study of cancer.

IC50 & Target[1][2]

MET.

体外研究(In Vitro)

Emibetuzumab (LY2875358) (100 nmol/L; 6 days) inhibits HGF-stimulated proliferation of H596. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Proliferation AssayCell L

体内研究(In Vivo)

Emibetuzumab (LY2875358) (10 mg/kg; i.v.; once a week for 5 weeks) inhibits in vivo growth of glioblastoma U87MG xenograft tumors in mice.
Emibetuzumab (10 or 20 mg/kg; i.v.; single) downregulates levels of MET and pMET in the tumors of mice.
Emibetuzumab (10 mg/kg; i.v.; once a week for 3, 5 or 6 weeks) exhibits antitumor effects on MET-amplified xenograft mouse tumor models. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

ClinicalTrial

参考文献

[1]. Liu L, et al. LY2875358, a neutralizing and internalizing anti-MET bivalent antibody, inhibits HGF-dependent and HGF-independent MET activation and tumor growth. Clin Cancer Res. 2014 Dec 1;20(23):6059-70.

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