Rilotumumab|872514-65-3|(AMG 102)-陌孚医药/Medlife

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Rilotumumab (Synonyms: AMG 102)

目录号: PL06059 纯度: ≥99%

CAS No. :872514-65-3

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PL06059-50mg	50mg	询价	询价
PL06059-100mg	100mg	询价	询价

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中文名称	Rilotumumab
英文名称	Rilotumumab
英文别名	Rilotumumab
Cas No.	872514-65-3
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情

Rilotumumab (AMG 102) 是一种 anti-HGF (抗肝细胞生长因子) 的单克隆抗体，抑制 HGF/MET 驱动的信号传导。Rilotumumab 具有抗肿瘤活性，可用于去势抵抗性前列腺癌 (CRPC) 和实体瘤的研究。

生物活性

Rilotumumab (AMG 102) is an anti-HGF (anti-hepatocyte growth factor) monoclonal antibody, inhibits HGF/MET-driven signaling. Rilotumumab shows anti-tumor activity, and can be used in castration-resistant prostate cancer (CRPC) and solid tumor research.

性状

Liquid

体外研究(In Vitro)

Rilotumumab (10 μg/mL; overnight) shows the decrease of MET phosphorylation at Y1234 and Y1235, and an increase in total MET. has not independently confirmed the accuracy of these methods. They are for reference only.Western Blot Analysis

体内研究(In Vivo)

Rilotumumab (intraperitoneal injection; 1.5 mg/kg; once two days; 11 d) treatment inhibits glioma cell growth in vivo. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 6-8-week-old BAL

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

ClinicalTrial

参考文献

[1]. Ryan CJ, et al. Targeted MET inhibition in castration-resistant prostate cancer: a randomized phase II study and biomarker analysis with rilotumumab plus mitoxantrone and prednisone. Clin Cancer Res. 2013 Jan 1;19(1):215-24.
[2]. Greenall SA, et al. EGFRvIII-mediated transactivation of receptor tyrosine kinases in glioma: mechanism and therapeutic implications. Oncogene. 2015 Oct 8;34(41):5277-87.

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