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Thiacetazone

目录号: PL05528 纯度: ≥98%

Thiacetazone (Thioacetazone) 是一种含硫脲的抗结核剂，也是一种具有口服活性抗生素。Thiacetazone 具有抗菌作用，可抑制结核分枝杆菌 H37Rv (Mycobacterium tuberculosis H37Rv) 的生长，其 MIC 值为 0.1 μg/mL。

CAS No. :104-06-3

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中文名称	Thiacetazone
中文别名	氨硫脲;4-乙酰氨基苯甲醛硫代卡巴棕;胺硫脲标准品;氨苯硫脲;硫脲胺;(4-乙酰氨基)苯甲醛缩氨基硫脲;N-[4-[(2-硫代氨基甲酰亚肼基)甲基]苯基]乙酰胺;结核安;硫醋腙;结核胺;胺苯硫脲;对乙酰氨基苯甲醛缩氨基硫脲;氨硫脲 1G
英文名称	Thiacetazone
英文别名	Acetamide,N-[4-[[2-(aminothioxomethyl)hydrazinylidene]methyl]phenyl]-;THIACETAZONE;4-Acetylaminobenzaldehyde thiosemicarbazon;4-Acetylaminobenzaldehyde thiosemicarbazone;N-[4-[(E)-(carbamothioylhydrazinylidene)methyl]phenyl]acetamide;(4-Acetylamino)benzaldehyde Thiosemicarbazone;N-[4-[(2-Carbamothioylhydrazono)methyl]phenyl]acetamide;Thiotebesin;Thiotebezin;Thiotebicina;Thizone;Tiacetazon;Tibicur;Tibion;Tibione;Tibizan;Tibon;Tibone;Tioacetazon;Tioatsetazon;Tiobicina;p-Acetylaminobenzaldehyde thiosemicarbazone;tbi;TB 1;Antib;Tubin;A 4081;4207rp;Diasan;Diazan;Tb I;Thioacetazone;AMITHIOZONE;Ambathizon;Benzothiozane;Conteben;Benzothiozon;Benthiozone;Parazone;Thiocarbazil;Thioacetazon;Thiosemicarbazone;Tubercazon;Thioazetazone;Thiacetone;Thiacetozone;Tebethione;Thioparamizone;Thioparamizon;Siocarbazone;Tiosecolo;Tiocarone;Tebalon;Livazone;Domakol;Thibone;Tebezon;Panrone;Novakol;Neustab;Neotibil;Berkazon;Tubigal;Thiomicid;Tebethion;Miviz;Amithiozone
Cas No.	104-06-3
分子式	C₁₀H₁₂N₄Os
分子量	236.29
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	Thiacetazone (Thioacetazone) 是一种含硫脲的抗结核剂，也是一种具有口服活性抗生素。Thiacetazone 具有抗菌作用，可抑制结核分枝杆菌 H37Rv (Mycobacterium tuberculosis H37Rv) 的生长，其 MIC 值为 0.1 μg/mL。

产品详情	Thiacetazone (Thioacetazone) 是一种含硫脲的抗结核剂，也是一种具有口服活性抗生素。Thiacetazone 具有抗菌作用，可抑制结核分枝杆菌 H37Rv (Mycobacterium tuberculosis H37Rv) 的生长，其 MIC 值为 0.1 μg/mL。
生物活性	Thiacetazone (Thioacetazone) is a thiourea-containing antitubercular agent and is an orally active antibiotic. Thiacetazone has antibacterial action, which inhibits growth of Mycobacterium tuberculosis H37Rv with a MIC value of 0.1 μg/mL.
性状	Solid
IC50 & Target[1][2]	MIC: 0.1 μg/mL (Mycobacterium tuberculosis H37Rv)
体外研究(In Vitro)	Thiacetazone is a prodrug that is activated by the mycobacterial monooxygenase EthA, which is also the activator of two other anti-tuberculosis agents, Ethionamide and Isoxyl. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	The K m and V max values for the N-deacetylation of Thiacetazone are 0.57 mM and 0.123 nmol of p-aminobenzaldehydethiosemicarbazone formed/min/mg cytosolic protein, respectively. The ability to metabolize Thiacetazone is the same in the livers of cat, mouse and human, but lagged significantly in that of rat. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. J L Stigliani, et al. New Insights Into the Chemical Behavior of S-oxide Derivatives of Thiocarbonyl-Containing Antitubercular Drugs and the Influence on Their Mechanisms of Action and Toxicity. Ann Pharm Fr. 2019 Mar;77(2):126-135. [2]. P Khanna, et al. Characteristics of a Cytosolic Arylacylamidase Metabolizing Thiacetazone. J Pharmacol Exp Ther. 1992 Sep;262(3):1225-31.

溶解度数据	In Vitro: DMSO : 100 mg/mL (423.21 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Thiacetazone

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