δ-Secretase inhibitor 11|842964-18-5|-陌孚医药/Medlife

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δ-Secretase inhibitor 11

目录号: PL02712 纯度: ≥99%

CAS No. :842964-18-5

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中文名称	δ-Secretase inhibitor 11
中文别名	7-吗啉-4-基苯并[1,2,5]恶二唑-4-基胺
英文名称	δ-Secretase inhibitor 11
英文别名	7-Morpholin-4-yl-benzo[1,2,5]oxadiazol-4-ylamine;δ-Secretase inhibitor 11
Cas No.	842964-18-5
分子式	C₁₀H₁₂N₄O₂
分子量	220.23
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	δ-Secretase inhibitor 11 (compound 11) 是一种口服有效、可透过血脑屏障的、无毒、选择性和特异性的 δ-secretase 抑制剂，其 IC₅₀ 为 0.7 μM。δ-Secretase inhibitor 11 与 δ-Secretase 的活性位点和变构位点相互作用。δ-Secretase inhibitor 11 可衰减 tau 和 APP (淀粉样前体蛋白)的裂解。δ-Secretase inhibitor 11 可改善tau P301S 和 5XFAD 转基因小鼠模型的突触功能障碍和认知功能障碍。δ-Secretase inhibitor 11 可用于阿尔茨海默病的研究。
生物活性	δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific δ-secretase inhibitor, with an IC 50 of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase. δ-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. δ-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. δ-Secretase inhibitor 11 can be used for Alzheimers disease research.
性状	Solid
IC50 & Target[1][2]	Caspase-3 31.86 ± 1. μM (IC50) Caspase-8 8
体外研究(In Vitro)	δ-Secretase inhibitor 11 (compound 11) (0-1 μM, 10 min) inhibits δ-secretase in a concentration- and time-dependent manner. δ-Secretase inhibitor 11 (0-1 μM) selectively blocks tau and APP (amyloid precursor protein) fragmentation by δ-secretase. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	δ-Secretase inhibitor 11 (compound 11) (10 mg/kg, Orally, once daily for 3 months) attenuates neuronal injury induced by OGD (oxygen-glucose deprivation), and specifically exerts neuroprotective actions. δ-Secretase inhibitor 11 (0-10 mg/kg, Orally, once daily for 1.5 and 3 months) inhibits δ-secretase activity, attenuates Aβ deposition and cognitive deficits in 5XFAD mouse model. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Zhang Z, et al. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimers disease. Nat Commun. 2017 Mar 27;8:14740.

溶解度数据	In Vitro: DMSO : 125 mg/mL (567.59 mM; Need ultrasonic)配制储备液

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