购物车0
产品总数：61419
CN2)%5bO-%5dC1%3dO)
| 商品编号 | 规格 | 价格 | 会员价 | 是否有货 | 数量 |
|---|---|---|---|---|---|
| PL01540-1mg | 1mg | ¥2571.00 | 请登录 |
|
|
| PL01540-5mg | 5mg | ¥7232.00 | 请登录 |
|
|
| PL01540-10mg | 10mg | ¥12536.00 | 请登录 |
|
|
| PL01540-50mg | 50mg | ¥36163.00 | 请登录 |
|
|
| PL01540-100mg | 100mg | 询价 | 询价 |
|
|
| PL01540-200mg | 200mg | 询价 | 询价 |
|
|
| PL01540-10mM*1mLinWater | 10mM*1mLinWater | ¥7956.00 | 请登录 |
|
| 中文名称 |
Lobaplatin
|
|---|---|
| 中文别名 |
洛铂;4-甲基-2-吡唑啉-5-酮;乐巴铂;乐铂
|
| 英文名称 |
Lobaplatin
|
| 英文别名 |
Platinum,[rel-(1R,2R)-1,2-cyclobutanedimethanamine-kN,kN'][(2S)-2-(hydroxy-kO)propanoato(2-)-kO]-, (SP-4-3)- (9CI);Platinum, [rel-(1R,2R)-1,2-cyclobutanedimethanamine-.kappa.N,.kappa.N'][(2S)-2-(hydroxy-.kappa.O)propanoato(2-)-.kappa.O]-, (SP-4-3)- (9CI) (CA INDEX NAME);Platinum,[rel-(1R,2R)-1,2-cyclobutanedimethanamine-kN,kN'][(2S)-2-(hydroxy-kO)propanoato(2-)-k...;d19466;Lobaplatin (D-19466);lobaplatin
|
| Cas No. |
135558-11-1
|
| 分子式 |
C9H18N2O3Pt
|
| 分子量 |
395.31
|
| 包装储存 |
Powder -20°C 3 years；4°C 2 years
|
| 详情描述 |
Lobaplatin (D-19466) 是铂 (II) 络合物的非对映混合物。Lobaplatin 将细胞周期阻滞在 G1 和 G2/M 期。Lobaplatin 通过增加 caspase和 Bax 的表达，降低 Bcl-2 的表达来诱导细胞凋亡 (apoptosis)。Lobaplatin 可用于癌症研究。
|
| 产品详情 |
Lobaplatin (D-19466) 是铂 (II) 络合物的非对映混合物。Lobaplatin 将细胞周期阻滞在 G1 和 G2/M 期。Lobaplatin 通过增加 caspase和 Bax 的表达，降低 Bcl-2 的表达来诱导细胞凋亡 (apoptosis)。Lobaplatin 可用于癌症研究。
|
|---|---|
| 生物活性 |
Lobaplatin (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin arrests cell cycle at G1 and G2/M phase. Lobaplatin induces apoptosis by increasing expressions of caspase and Bax, decreasing expression of Bcl-2. Lobaplatin can be used for research of cancer.
|
| 性状 |
Solid
|
| 体外研究(In Vitro) |
Lobaplatin (D-19466, 0.25-32 μg/mL; 24-72 h) exhibits anti-proliferative activities against esophageal squamous cell carcinoma (ESCC) cell lines.Lobaplatin (0-16 μg/mL; 48 h) induces esophageal squamous cell carcinoma (ESCC) apoptosis and modulates expression of apoptosis-related proteins.Lobaplatin (1.45 μg/mL; 0-48 h; SMMC-7721 cells) arrests cell cycle progression at G1 and G2/M phases in a time-dependent manner.Lobaplatin (1.45 μg/mL; 0-48 h; SMMC-7721 cells) inhibits the mRNA levels of cyclin B, CDK1, and CDC25C phosphatase, down-regulates Rb/E2F complexes and up-regulates of CDK inhibitors. has not independently confirmed the accuracy of these methods. They are for reference only.
|
| 体内研究(In Vivo) |
Lobaplatin (5 and 10 mg/kg; i.p.; once a week, for 3 weeks) suppresses tumor growth of esophageal squamous cell carcinoma (ESCC) xenograft. has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere.
|
| 储存方式 |
Powder -20°C 3 years；4°C 2 years
|
| ClinicalTrial |
|
| 参考文献 |
[1]. Du L, et, al. Antitumor activity of Lobaplatin against esophageal squamous cell carcinoma through caspase-dependent apoptosis and increasing the Bax/Bcl-2 ratio. Biomed Pharmacother. 2017 Nov;95:447-452.[2]. Wu Q, et, al. Lobaplatin arrests cell cycle progression in human hepatocellular carcinoma cells. J Hematol Oncol. 2010 Oct 31;3:43.
|
| 溶解度数据 |
In Vitro: H2O : ≥ 50 mg/mL (125.84 mM; DMSO can inactivate Lobaplatins activity)
|
|---|
1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
Copyright © 2025 陌孚医药 All rights reserved 未经授权禁止拷贝本站所有资料，如有违反，将追究法律责任。
沪ICP备2023012080号 | 
沪公网安备31011402010657号
扫码关注公众号
产品使用指南
