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PEAQX tetrasodium hydrate

(Synonyms: NVP-AAM077 tetrasodium hydrate)

目录号: PL02582 纯度: ≥98%

PEAQX (NVP-AAM077) tetrasodium hydrate 是有效的、选择性的、口服有效的 NMDA 拮抗剂，其对 hNMDAR 1A/2A 和 hNMDAR 1A/2B 的 IC50 值分别为 270 nM 和 29600 nM。

商品编号	规格	价格	会员价
PL02582-5mg	5mg	¥1928.00	请登录
PL02582-10mg	10mg	¥3214.00	请登录
PL02582-50mg	50mg	¥10286.00	请登录
PL02582-100mg	100mg	询价	询价
PL02582-200mg	200mg	询价	询价
PL02582-10mM*1mLinWater	10mM*1mLinWater	¥2377.00	请登录

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中文名称	PEAQX tetrasodium hydrate
英文名称	PEAQX tetrasodium hydrate
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	PEAQX (NVP-AAM077) tetrasodium hydrate 是有效的、选择性的、口服有效的 NMDA 拮抗剂，其对 hNMDAR 1A/2A 和 hNMDAR 1A/2B 的 IC50 值分别为 270 nM 和 29600 nM。

产品详情	PEAQX (NVP-AAM077) tetrasodium hydrate 是有效的、选择性的、口服有效的 NMDA 拮抗剂，其对 hNMDAR 1A/2A 和 hNMDAR 1A/2B 的 IC₅₀ 值分别为 270 nM 和 29600 nM。
生物活性	PEAQX (NVP-AAM077) tetrasodium hydrate is a potent, selective and orally active NMDA antagonist, with IC 50 values of 270 nM and 29600 nM for hNMDAR 1A/2B and hNMDAR 1A/2B, respectively.
性状	Solid
IC50 & Target[1][2]	NMDA Receptor
体外研究(In Vitro)	PEAQX (3 μM) produces similar caspase-3 activation, while NVP-AAM007 is approximately three-fold more potent. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	PEAQX (10-40 mg/kg) dose-dependently increased cortical caspase-3 activity following sub-chronic administration. PEAQX (10 and 20 mg/kg) shows enhanced locomotor activity in response to PCP challenge (4 mg/kg on PN28-35) compared to saline pretreatment (F 3, 73 =4.99). PEAQX (10 mg/kg, ip) antagonizes the effects of PRE084 on CaMKIV-TORC1-CREB and BDNF, even for learning and memory impairment. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Auberson YP, et al. 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1099-102. [2]. Anastasio NC, et al. Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits. Neuroscience. 2009 Nov 10;163(4):1181-91.

溶解度数据	In Vitro: H₂O : 25.5 mg/mL (45.52 mM; Need ultrasonic and warming)配制储备液

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[1]. Auberson YP, et al. 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1099-102.
[2]. Anastasio NC, et al. Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits. Neuroscience. 2009 Nov 10;163(4):1181-91.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

PEAQX tetrasodium hydrate

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