您当前的位置：

CDDO-EA

(Synonyms: CDDO ethyl amide; TP319; RTA 405)

目录号: PL02522 纯度: ≥99%

CDDO-EA 是一种 NF-E2 相关因子 2 /抗氧化反应元件 (Nrf2/ARE) 激活剂。

CAS No. :932730-51-3

商品编号	规格	价格	会员价
PL02522-5mg	5mg	¥1725.00	请登录
PL02522-10mg	10mg	¥3145.00	请登录
PL02522-50mg	50mg	¥6985.00	请登录
PL02522-100mg	100mg	¥9415.00	请登录
PL02522-200mg	200mg	¥12695.00	请登录
PL02522-500mg	500mg	询价	询价
PL02522-10mM*1mLinDMSO	10mM*1mLinDMSO	¥4768.00	请登录
PL02522-1 mL x 10 mM (in DMSO)		¥1985.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

*注意事项:下单时请联系销售核实产品价格及货期，避免后续产生不便，感谢支持!

加入购物车在线咨询收藏产品大包装询价

中文名称	CDDO-EA
中文别名	CDDO-EA
英文名称	CDDO-EA
英文别名	CDDO-EA;CDDO ethyl amide;RTA405;RTA-405;TP319;TP-319;2-Cyano-N-ethyl-3,12-dioxooleana-1,9(11)-dien-28-amide (ACI);2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic ethyl amide;2-Cyano-3,12-dioxoolen-1,9-dien-28-oic acid ethyl amide;RTA 405;TP 319
Cas No.	932730-51-3
分子式	C₃₃H₄₆N₂O₃
分子量	518.73
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	CDDO-EA 是一种 NF-E2 相关因子 2 /抗氧化反应元件 (Nrf2/ARE) 激活剂。

产品详情	CDDO-EA 是一种 NF-E2 相关因子 2 /抗氧化反应元件 (Nrf2/ARE) 激活剂。
生物活性	CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.
性状	Solid
IC50 & Target[1][2]	Nrf2/ARE
体外研究(In Vitro)	CDDO-EA potently activates Nrf2/ARE in a cell culture model of ALS and in the G93A SOD1 mouse model of ALS. CDDO-EA is a potent inducer of apoptosis in A549 lung cancer cells, as shown both by PARP cleavage and Annexin staining. CDDO-EA is more potent than CDDO itself as inducers of heme oxygenase-1 (HO-1). In RAW264.7 macrophage-like cells, CDDO-EA is 7-fold more potent than CDDO as suppressors of the ability of IFN-γ to induce iNOS. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	The survival analysis shows that G93A mice treated with CDDO-EA, compared to G93A littermate controls, lives significantly longer. CDDO-EA treatment increases the life-span by 20.6 days from 124.05±3.7 days to 144.72±8.1 days (16.6%) (p<0.001). In CDDO-EA-treated G93A mice, the age of death is 141.4±5.2 days and the duration from the age of onset to the age of death is 57.6±7.6 days, which means that the age of death from onset is prolonged by 17.5 days (43%). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Neymotin A, et al. Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis. Free Radic Biol Med. 2011 Jul 1;51(1):88-96. [2]. Liby K, et al. The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice. Cancer Res. 2007 Mar 15;67(6):2414-9.

溶解度数据	In Vitro: DMSO : 16.67 mg/mL (32.14 mM; ultrasonic and warming and heat to 80°C)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

[1]. Neymotin A, et al. Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis. Free Radic Biol Med. 2011 Jul 1;51(1):88-96.
[2]. Liby K, et al. The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice. Cancer Res. 2007 Mar 15;67(6):2414-9.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

CDDO-EA

相关产品

The molarity calculator equation

The dilution calculator equation