S-Allylmercaptocysteine|2281-22-3|-陌孚医药/Medlife

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S-Allylmercaptocysteine

目录号: PL04092 纯度: ≥95%

CAS No. :2281-22-3

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PL04092-100mg	100mg	询价	询价
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中文名称	S-Allylmercaptocysteine
英文名称	S-Allylmercaptocysteine
英文别名	(R)-S-(Allylthio)cysteine;(S)-allylmercaptocysteine;3-allyldisulfanyl-L-alanine;CySSA;S-(2-Propenylthio)-L-cysteine;S-(Allylthio)cysteine;S-2-propenylmercapto-L-cysteine;S-allylmercapto-L-cysteine;S-allylmercaptocysteine
Cas No.	2281-22-3
分子式	C₆H₁₁NO₂S₂
分子量	193.29
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	S-allylmercaptocysteine 是一种从大蒜中提取的有机硫化合物，对各种肺部疾病具有抗炎和抗氧化作用。S-allylmercaptocysteine 通过多种途径发挥抗癌作用，如通过 TGF-β 信号通路诱导癌细胞凋亡 (apoptosis)，或通过降低 NF-κb 活性和上调 Nrf2 来达到抗炎和抗氧化的作用。
生物活性	S-allylmercaptocysteine, an organic sulfur compound extracted from garlic, has anti-inflammatory and anti-oxidative effects for various pulmonary diseases. S-allylmercaptocysteine achieves its anti-cancer effect through a variety of pathways such as inducing the apoptosis of cancer cells through the TGF-β signaling pathway, or reducing the NF-κB activity and up-regulating Nrf2 to achieve the effects of anti-inflammation and anti-oxidation.
性状	Solid
体外研究(In Vitro)	S-Allylmercaptocysteine attenuates cisplatin-induced nephrotoxicity through suppression of apoptosis, oxidative stress, and inflammation. S-Allylmercaptocysteine (400 μM; 48 hours) induces apoptosis evaluated by detecting the activated caspase 3 and cleaved PARP in SW620, SW480, and Caco-2 cells. Both activated caspase 3 and cleaved PARP1 are found in the cells treated with SAMC while no activated PARP1 and caspase 3 are found in the untreated control cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	S-Allylmercaptocysteine (25 and 50 mg/kg; oral gavage) could significantly ameliorate the pathological structure, and decrease inflammatory cell infiltration and pro-inflammatory cytokines in bronchoalveolar lavage fluid (BALF) in BLM-induced pulmonary fibrosis mice. S-Allylmercaptocysteine shows an anti-fibrosis effect by increasing anti-oxidants like HO-1, GSH and SOD as well as decreasing hydroxyproline (HYP) in BLM-induced mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Tong D, et al. S-allylmercaptocysteine promotes MAPK inhibitor-induced apoptosis by activating the TGF-β signaling pathway in cancer cells. Oncol Rep. 2014;32(3):1124-1132. [2]. Zhu X, et al. S-Allylmercaptocysteine Attenuates Cisplatin-Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation. Nutrients. 2017;9(2):166. Published 2017 Feb 20.

溶解度数据	In Vitro: H₂O : 1 mg/mL (5.17 mM; ultrasonic and warming and heat to 60°C)DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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