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AZD7507

目录号: PL02330 纯度: ≥99%

AZD7507 为一种有效的、可口服的 CSF-1R 抑制剂，具有抗肿瘤活性。

CAS No. :1041852-85-0

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中文名称	AZD7507
中文别名	AZD7507
英文名称	AZD7507
英文别名	AZD7507;4-(2-fluoro-4-methylanilino)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide;AMY16926;BDBM50492685;A16886;D77979;4-((2-fluoro-4-methylphenyl)amino)-6-(4-(2-hydroxyethyl)piperazin-1-yl)-7-methoxycinnoline-3-carboxamide
Cas No.	1041852-85-0
分子式	C₂₃H₂₇FN₆O₃
分子量	454.50
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	AZD7507 为一种有效的、可口服的 CSF-1R 抑制剂，具有抗肿瘤活性。

产品详情	AZD7507 为一种有效的、可口服的 CSF-1R 抑制剂，具有抗肿瘤活性。
生物活性	AZD7507 is a potent and orally active CSF-1R inhibitor, with antitumor activity.
性状	Solid
IC50 & Target[1][2]	CSF-1R
体外研究(In Vitro)	AZD7507 (Compound 31) inhibits the proliferation of 3T3 cells engineered to express CSF-1R and stimulated with CSF-1 (IC50, 32 nM), shows inhibitory activity against hERG and NaV1.5, with IC50s of >30 and 26 μM. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	AZD7507 has good rat oral PK, with in vivo clearance of 7 mL/min/kg and 42% bioavailability. In the canine L-type Ca channel assay, the IC 50 is >20 μM. AZD7507 significantly decreases the number of CD68 macrophages in mice, and also reduces the volume and mass in mice bearing CC-LP-1 and SNU-1079 cells, but not WITT-1 cells. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Scott DA, et al. Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4591-6. [2]. Boulter L, et al. WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. Send to J Clin Invest. 2015 Mar 2;125(3):1269-85.

溶解度数据	In Vitro: DMSO : 130 mg/mL (286.03 mM; Need ultrasonic)配制储备液

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[1]. Scott DA, et al. Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4591-6.
[2]. Boulter L, et al. WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. Send to J Clin Invest. 2015 Mar 2;125(3):1269-85.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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