Flupirtine-d4 hydrochloride

目录号: PL01834
Flupirtine-d4 (D 9998-d4) hydrochloride 是 Flupirtine 的氘代物。Flupirtine (D 9998) hydrochloride 是神经元钾通道开放剂,同时还能拮抗 NMDA 受体。
CAS No. :1324717-75-0
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PL01834-1mg 1mg 询价 询价
PL01834-10mg 10mg 询价 询价
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中文名称
Flupirtine-d4 hydrochloride
中文别名
氟吡丁,盐酸D4
英文名称
Flupirtine-d4 hydrochloride
英文别名
Flupirtine - d4 hydrochloride;Flupirtine-d4 Hydrochloride Salt;N-[2-Amino-6-[[4-fluorophenyl-d4)methyl]amino]-3-pyridinyl]carbamic acid ethyl ester hydrochloride
Cas No.
1324717-75-0
分子式
C15H18ClFN4O2
分子量
344.81
包装储存
Please store the product under the recommended conditions in the Certificate of Analysis.
详情描述
Flupirtine-d4 (D 9998-d4) hydrochloride 是 Flupirtine 的氘代物。Flupirtine (D 9998) hydrochloride 是神经元钾通道开放剂,同时还能拮抗 NMDA 受体。
产品详情
Flupirtine-d4 (D 9998-d4) hydrochloride 是 Flupirtine 的氘代物。Flupirtine (D 9998) hydrochloride 是神经元钾通道开放剂,同时还能拮抗 NMDA 受体。
生物活性
Flupirtine-d4 (D 9998-d4) hydrochloride is the deuterium labeled Flupirtine. Flupirtine(D 9998) hydrochloride is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.
体外研究(In Vitro)
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2]. Kornhuber J, et al. Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltageindependent potassium channels. Rapid communication. J Neural Transm. 1999;106(9-10):857-67.;Klinger F, et al. Concomitant facilitati
搜索质检报告(COA)
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2]. Kornhuber J, et al. Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltageindependent potassium channels. Rapid communication. J Neural Transm. 1999;106(9-10):857-67.;Klinger F, et al. Concomitant facilitati

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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