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(+)-Catechin hydrate.

(Synonyms: (+)-水合儿茶素)

目录号: PC60488 纯度: ≥99%

(+)-Catechin hydrate 抑制环加氧酶-1 (COX-1) , IC50 为 1.4 μM。(+)-Catechin hydrate 抑制环加氧酶-1 (COX-1) , IC50 为 1.4 μM。

CAS No. :225937-10-0

商品编号	规格	价格	会员价	是否有货	数量
PC60488-1mg	1mg	询价	询价

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中文名称	(+)-Catechin hydrate.
中文别名	(+)-儿茶素,儿茶酚,儿茶酸,邻苯二酚;(+/-)-儿茶精;DL-儿茶素;D(+)-儿茶精;D(+)-儿茶素(四水);D(+)-儿茶酸;反式-3,3ˊ,4ˊ,4,7-五羟基黄烷;四水合-D(+)儿茶素;(+)-儿茶精;(+)-儿茶素(一水物);(2R,3S)-2-(3,4-二羟基苯基)-3,4-二氢-1(2H)-苯并吡喃-3,5,7-三醇一水物;水合儿茶素;(+)-儿茶精水合物;(+)-儿茶精 (+)-儿茶素;(+)-儿茶素;(+)-儿茶素标准品;(+)-儿茶素水合物;(+)-儿茶素（标准品）;儿茶精水合物;儿茶素;(+)-儿茶精-3;(+)儿茶素;(2R,3S)-2-(3,4-二羟基苯基)-3,4-二氢-1(2H)-苯并吡喃-3,5,7-三醇;(+)-水合儿茶素
英文名称	(+)-Catechin hydrate
英文别名	(2R,3S)-2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol hydrate;(2R,3S)-2-(3,4-DIHYDROXYPHENYL)-3,4-DIHYDRO-1(2H)-BENZOPYRAN-3,5,7-TRIOL;(2R,3S)-2-(3,4-DIHYDROXYPHENYL)-3,4-DIHYDRO-1(2H)-BENZOPYRAN-3,5,7-TRIOL HYDRATE;(+)-3,3',4',5,7-FLAVANPENTOL HYDRATE;(+)-3,3',4',5,7-FLAVANPENTOL MONOHYDRATE;3,3',4',5,7-PENTAHYDROXYFLAVANE HYDRATE;(+)-C;(+)-CATECHIN HYDRATE;(+)-CATECHIN MONOHYDRATE;CATECHOL (FLAVAN), HYDRATE;CATECHUIC ACID (HYDRATE);(+)-CYANIDOL-3;(+)-CYANIDOL-3, HYDRATE;CYANIDOL HYDRATE;D-CATECHIN;D-(+)-CATECHIN HYDRATE;D-CATECHIN HYDRATE;D-CATECHOL HYDRATE;(+)-TRANS-3,3',4',5,7-PENTAHYDROXYFLAVANE HYDRATE;TRANS-3,3',4',5,7-PENTAHYDROXYFLAVANE HYDRATE;(+)-Catechin (hydrate);(±)-Catechin hydrate;(2R,3S)-2-(3,4-Dihydroxyphenyl)-chroman-3,5,7-triol hydrate;Catechin hydrate;(+)-Cyanidol-3,(2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol;Cefixoral-13C,15N2;FK-027-13C,15N2;(+)-catechin;Cianidanol;CATECHIN;Catechuic acid;Cyanidanol;Catechinic acid;Catergen;Cianidol;(+)-Cyanidanol;(+)-Catechol;(+)-Cyanidan-3-ol;Biocatechin;D-(+)-Catechin;Dexcyanidanol;Catechin (flavan);Catechol (flavan);D-Catechol;(2R,3S)-Catechin;(2R,3S)-2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol;Gambier;3-Cyanidanol, (+)-;Cianidanolum;Catechu;Transepar;Katha;(2R,3S)-(+)-Catechin;(+)-Cianidanol;Cutch (dye);3,3',4',5,7-Flavanpentol;(+)-Cyanidanol-3;CCRI
Cas No.	225937-10-0
分子式	C₁₅H₁₄O₆
分子量	290.27
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；
详情描述	(+)-Catechin hydrate 抑制环加氧酶-1 (COX-1) , IC50 为 1.4 μM。(+)-Catechin hydrate 抑制环加氧酶-1 (COX-1) , IC50 为 1.4 μM。

生物活性	(+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.
性状	Solid
IC50 & Target[1][2]	COX-1 1.4 μM (IC50)

体外研究(In Vitro)

(+)-Catechin exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. A dose-dependent reduction in color is observed after 24 hours of treatment with (+)-Catechin, and 54.76% of the cells are dead at the highest concentration of (+)-Catechin tested (160 μg/mL) whereas the IC50 of (+)-Catechin is achieved at 127.62 μg/mL (+)-Catechin. A dose- and time-dependent increase in the induction of apoptosis is observed when MCF-7 cells are treated with (+)-Catechin. When compare to the control cells at 24 hours, 40.7 and 41.16% of the cells treated with 150 μg/mL and 300 μg/mL (+)-Catechin, respectively, undergo apoptosis. The expression levels of Caspase-3, -8, and -9 and p53 in MCF-7 cells treated with 150 μg/mL (+)-Catechin for 24 h increase by 5.81, 1.42, 3.29, and 2.68 fold, respect

体内研究(In Vivo)

Animals treated with (+)-Catechin at the lowest tested dose, i.e., 50 mg/kg, p.o. have spent comparatively more time in exploring the novel object in the choice trial, however, the difference is not statistically significant. (+)-Catechin prevents the time-induced episodic memory deficits in a dose-dependent manner, the most effective being 200 mg/kg, p.o.. Treatment with (+)-Catechin prevents the rise in MPO level compare to DOX alone treatment group (21.98±9.44 and 36.76±4.39% in the hippocampus and the frontal cortex respectively).Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

ClinicalTrial

结构分类

Flavonoids
Flavan

来源

Plants

溶解度数据	体外研究: DMSO : 50 mg/mL (Need ultrasonic) 体内研究: 请根据您的实验动物和给药方

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

(+)-Catechin hydrate.

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