L-Phenylephrine|59-42-7|(去氧肾上腺素; (R)-(-)-Phenylephrine; L-Phenylephrine)-陌孚医药/Medlife

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L-Phenylephrine (Synonyms: 去氧肾上腺素; (R)-(-)-Phenylephrine; L-Phenylephrine)

目录号: PC11424 纯度: ≥98%

CAS No. :59-42-7

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PC11424-10mM (in 1mL DMSO)	10mM (in 1mL DMSO)	¥637.00	请登录

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中文名称

L-Phenylephrine

中文别名

苯福林;去羟肾上腺素;去氧肾上腺;新辛内井林;新交感酚;L-苯肾上腺素;L-Phenylephrine; L-苯肾上腺素;L-去氧肾上腺素碱;苯福林碱;苯肾上腺素;去氧肾上腺素;去氧肾上腺素碱;新福林;3-羟基-α-((甲基氨基)甲基)-苄醇;small>-苯肾上腺素;(R)-(-)-3-羟基-α-(甲基氨甲基)苄醇;(R)-(-)-3-[1-羟基-2-(甲胺基)乙基]苯酚;(R)-(-)-1-(3-羟苯基)-2-(甲胺基)乙醇;(R)-(-)-苯肾上腺素;3-羟基-alpha-((甲基氨基)甲基)-苄醇

英文名称

L-Phenylephrine

英文别名

(-)-Phenylephrine Base;Phenylephrine;(-)-1-(3-hydroxyphenyl)-2-methylaminoethanol;L-Phenylephrine;R-(γ)-Phe;L<;Adrianol;Isophrin;Mesaton;Mesatone;Mezaton;Mydfrin;Neophryn;Nostril;Prefrin;(R)-(-)-3-[1-Hydroxy-2-(methylamino)ethyl]phenol;(R)-(-)-3-Hydroxy-α-(methylaminomethyl)benzyl Alcohol;(R)-(-)-1-(3-Hydroxyphenyl)-2-(methylamino)ethanol;(R)-(-)-Phenylephrine;3-Hydroxy-alpha-((methylamino)methyl)-benzyl alcohol;Metasympatol;Metasynephrine;Neosynephrine;Metaoxedrin;m-Oxedrine;Metaoxedrine;Visadron;m-Sympatol;m-Synephrine;m-Sympathol;R(-)-Phenylephrine;Metaoxedrinum;Phenylephrinum;Fenilefrina;Mesatonum;m-Methylaminoethanolphenol;Neo-Synephrine;Isophrim;Ak-dilate;Ah-Chew;Spersaphrine;Cyclomydril;Dionephrine;Ocugestrin;Neofrin;Duration;Phenoptic;Doktors;Dilatair;3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol

Cas No.

59-42-7

分子式

C₉H₁₃NO₂

分子量

167.21

包装储存

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

(R)-(-)-Phenylephrine is a selective α₁-adrenoceptor agonist primarily used as a decongestant.

性状

Solid

体外研究(In Vitro)

(R)-(-)-Phenylephrine is a selective α₁-adrenoceptor agonist with pK_i values of 5.86, 4.87 and 4.70 for α_1D, α_1B and α_1A receptors respectively. Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca()/CaN/NFAT pathway mediates phenylephrine -induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Perfusion of hearts with 100 μM phenylephrine causes a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α₁-adrenoceptor agonists such as phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes. Phenylephrine could increase the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

ClinicalTrial

参考文献

[1]. Ford AP, et al. Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications foralpha1-adrenoceptor classification. Br J Pharmacol. 1997 Jul;121(6):1127-35. [Information]

[2]. Minneman KP, et al. Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36. [Information]

[3]. Wang J, et al. Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway. Front Biosci (Landmark Ed). 2016 Jan 1;21:502-13. [Information]

[4]. Lazou A, et al. Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart. Biochem J. 1998 Jun 1;332 ( Pt 2):459-65. [Information]

[5]. Li NJ, et al. Effect of phenylephrine on alveolar fluid clearance in ventilator-induced lung injury. Chin Med Sci J. 2013 Mar;28(1):1-6. [Information]

溶解度数据

体外研究:

DMSO : 50 mg/mL (299.03 mM; Need ultrasonic)

H₂O : 5 mg/mL (29.90 mM; Need ultrasonic)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.9805 mL	29.9025 mL	59.8050 mL
5 mM	1.1961 mL	5.9805 mL	11.9610 mL
10 mM	0.5981 mL	2.9903 mL	5.9805 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： PBS
Solubility: 10 mg/mL (59.81 mM); Clear solution; Need ultrasonic and warming

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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