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Coenzyme Q10 (Synonyms: 辅酶Q10; CoQ10; Ubiquinone-10; Ubidecarenone)
目录号: PC13499 纯度: ≥98%
CAS No. :303-98-0
商品编号 规格 价格 会员价 是否有货 数量
PC13499-200mg 200mg ¥997.50 请登录
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中文名称
Coenzyme Q10
中文别名
辅酶Q10;癸烯醌;泛醌;泛癸利酮;辅酵素Q10;2-(3,7,11,15,19,23,27,31,35,39-十甲基-2,6,10,14,18,22,26,30,34,38-四十碳十烯基)-5,6-二甲氧基-3-甲基-p-苯醌;辅酶 Q-10;水溶性辅酶 Q-10;还原性辅酶 Q-10;还原及水溶性辅酶 Q-10;辅酶;Coenzyme Q10 辅酶Q10;泛癸利酮 EP标准品;泛癸利酮系统适用性 EP标准品;防腐涂料用纳米二氧化锆液体;辅酶 Q10(Ubidecarenone);辅酶Q10 USP标准品;辅酶Q10 标准品;辅酶Q10 脂溶性抗氧化剂;辅酶Q10(Natural)(P);辅酶Q10(标准品);辅酶Q10,Co Enzyme Q10,植物提取物,标准品,对照品;辅酶Q10,对照品;辅酶Q10,泛醌;辅酶Q10-D5;辅酶Q10-D6;辅酶Q10标准品(JP);辅酶Q10干粉(水溶型);辅酶Q10环境 USP标准品;辅酶Q10纳米乳液;辅酶Q10原药;隔热涂料用纳米二氧化锆分散液;纳米二氧化锆醇分散浆;纳米二氧化锆醇溶液;纳米二氧化锆分散浆;纳米二氧化锆分散液;纳米二氧化锆水性液体;纳米二氧化锆酮类分散液;纳米二氧化锆油性液体;纳米氧化锆 分散液;纳米氧化锆醇分散液;纳米氧化锆水分散液;纳米氧化锆水性浆料;水溶性辅酶Q10;涂料用纳米二氧化锆分散液;医药级辅酶Q10;2-(3,7,11,15,19,23,27,31,35,39-十甲基-2,6,10,14,18,22,26,30,34,38-四十烷十基)-5,6-二甲氧基-3-甲基-2,5-环己二烯-1,4-二酮;2-(3,7,11,15,19,23,27,31,35,39-癸甲基-2,6,10,14,18,22,26,30,34,38-四十癸烯基)-5,6-二甲氧基-3-甲基-p-苯醌;2,3-二甲氧基-5-甲基-6[3-甲基丁烯基-2]苯醌;泛醌10;泛醌-50;范醌;辅酶Q10(泛癸利酮,泛醌,癸烯醌,万有醌-10,辅酵素Q10);辅酶R10;万有醌;万有醌-10;氧化型辅酶Q10;辅酶 Q10
英文名称
Coenzyme Q10
英文别名
coenzyme Q10;coenzyme Q10 synthetic;ubidecarenone;coenzyme Q-10;Co Q10;Coenzymen Q10;Water-soluble Coenzymen Q10;Hydrosoluble Coenzymen Q10;QH 10;Water-soluble QH10;coenzyme q10 UBIDECARENONE;COENZYME Q10(Natural)(P) PrintBack;COENZYME Q10(Synthetic)(P);Q10 COENZYME;Ubiquinone 10;Carenone;Coenz10;CoenzyMe Q-199;Coenzyme?Q10;Coenzyme?Q10,Q-10,Ubiquinone 50;eiquinon;Ensorb;Kudesan;Liquid-Q;neuqinon;Q10;Q-10;Q-10 Ubiquinone 50 Ubiquinone-10;Q-Gel;Ubiquinone 50;ubiquinone Q10;Ubiquinone-10;Ubiquinone-Q10;Coenzyme Q10;Ubiquinone
Cas No.
303-98-0
分子式
C59H90O4
分子量
863.36
包装储存

-20°C, sealed storage, away from moisture and light

*该产品在溶液状态不稳定,建议您现用现配,即刻使用。

生物活性

Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.

性状

Solid

IC50 & Target[1][2]

Human Endogenous Metabolite

 

体外研究(In Vitro)

Coenzyme Q10 is an obligatory member of the respiratory chain in the mitochondria of all cells. Therefore, it is an essential ingredient in the formation of adenosine triphosphate (ATP), the source of energy in most cellular processes. Coenzyme Q10 is located in the mitochondria, lysosomes, and Golgi and plasma membranes, and provides an antioxidant action either by direct reaction with free radicals or by regeneration of tocopherol and ascorbate from their oxidised state. Coenzyme Q10 is a popular dietary supplement because of its recognition by the public as an important nutrient in supporting human health. The rationale for the use of Coenzyme Q10 as a therapeutic agent in several cardiovascular and degenerative neurologic and neuromuscular diseases is based upon its fundamental role in mitochondrial function and cellular bioenergetics.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Because of its hydrophobicity and large molecular weight, absorption of dietary Coenzyme Q10 is slow and limited. In the case of dietary supplements, solubilized Coenzyme Q10 formulations show enhanced bioavailability. The Tmax is around 6 h, with an elimination half-life of about 33 h. The reference intervals for plasma Coenzyme Q10 range from 0.40 to 1.91 mM in healthy subjects. With Coenzyme Q10 supplements there is reasonable correlation between increase in plasma Coenzyme Q10 and ingested dose up to a certain point. Animal data show that Coenzyme Q10 in large doses is taken up by all tissues including heart and brain mitochondria. In 12-month-old rats administration of coenzyme Q10 results in significant increases in cerebral cortex mitochondrial concentrations of coenzyme Q10. Oral administration of coenzyme Q10 markedly attenuates striatal lesions produced by systemic administration of 3-nitropropionic acid and significantly increases life span in a transgenic mouse model of familial amyotrophic lateral sclerosis.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

-20°C, sealed storage, away from moisture and light

*该产品在溶液状态不稳定,建议您现用现配,即刻使用。

ClinicalTrial
结构分类
参考文献
溶解度数据
体外研究: 

DMF : 20 mg/mL (23.17 mM; ultrasonic and warming and heat to 60°C)

Ethanol : 2.5 mg/mL (2.90 mM; Need ultrasonic)

DMSO : 1 mg/mL (1.16 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

配制储备溶液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1583 mL 5.7915 mL 11.5829 mL
5 mM 0.2317 mL 1.1583 mL 2.3166 mL
10 mM 0.1158 mL 0.5791 mL 1.1583 mL
*

建议根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备溶液;该产品在溶液状态不稳定,建议您现用现配,即刻使用

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    建议依照次序添加每种溶剂: 20% HP-β-CD in saline

    Solubility: 13.33 mg/mL (15.44 mM); Suspended solution; Need ultrasonic

  • 2.

    建议依照次序添加每种溶剂: 10% DMF    90% (20% SBE-β-CD in saline)

    Solubility: 3 mg/mL (3.47 mM); Suspended solution; Need ultrasonic

*
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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