Gallic acid.|149-91-7|(没食子酸; 3,4,5-Trihydroxybenzoic acid)-陌孚医药/Medlife

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Gallic acid. (Synonyms: 没食子酸; 3,4,5-Trihydroxybenzoic acid)

目录号: PC13517 纯度: ≥98%

CAS No. :149-91-7

商品编号	规格	价格	会员价	是否有货	数量
PC13517-20mg	20mg	¥84.75	请登录
PC13517-10mM (in 1mL DMSO)	10mM (in 1mL DMSO)	¥780.00	请登录

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中文名称

Gallic acid.

中文别名

没食子酸;没食子酸(标准品);3,4,5-三羟基苯甲酸,五倍子酸,棓酸,没食子酸;没食子酸(3,4,5-三羟基苯甲酸,五倍子酸,棓酸,没食子酸(无水));GALLIC ACID 没食子酸;5-三羟基苯甲酸;没食子酸（无水）;3,4,5-三羟基苯甲酸;■没食子酸;?酸;倍酸;呋喃西林;林泽兰内酯B;没食子酸标准品;没食子酸(P);没食子酸（一水）;没食子酸,AR;没食子酸,CP;没食子酸,Gallic Acid,植物提取物,标准品,对照品;没食子酸.芹菜素.莽草酸.蒙花苷.青蒿素.双氢青蒿素;没食子酸Gallic acid;没食子酸对照品;没食子酸水合物;没食子酸乙酯;无水倍酸;五倍子酸;棓酸;分析对照品;没食子酸 3,4,5-三羟基苯甲酸,五倍子酸;没食子酸一水合物;没食子酸(一水物);没食子酸,3,4,5-三羟基苯甲酸;没食子酸,无水倍酸;石墨酸;氧化石墨;没食子酸99%;没食子酸(98%)

英文名称

Gallic acid

英文别名

Gallic acid;3,4,5-TRIHYDROXYBENZOIC ACID;3,4,5-TRIOXYBENZOIC ACID;AKOS 214-65;BETZ 0276;GALLIC ACID-1-HYDRATE;RARECHEM AL BE 0070;TIMTEC-BB SBB008781;3,4,5-trihydroxy-benzoicaci;gallic;Gallussaure;Kyselina 3,4,5-trihydroxybenzoova;Kyselina gallova;3,4,5-Trihydroxybezoic acid;Gallic acid (Monohydrate or Anhydrous);Benzoic acid, 3,4,5-trihydroxy-;3,4,5-trihydroxybenzoic acid, anhydrous;GALLIC ACID- CHINESE;2-Deoxy-2-thioarachidonoylphosphatidylcholine;Gallic acid (Monohydrate or Anhydrous) (3,4,5-Trihydroxybenzoic acid );Gallic acid monohydrate;GALLIC ACID(AS);GALLIC ACID(P);GALLIC ACID(P) PrintBack;GALLIC ACID, NATURAL STANDARD;Gallic acid;3,4,5-trihydroxybenzenoic Acid;Galloyl alcohol;graphite oxide;graphitic acid;Pyrogallol-5-carboxylic acid;[ "3", "4", "5-Trihydroxybenzoic acid" ];Gallic acid 0;3;kyselinagallova;gallate;Gallic acid, tech.;GALOP;3,4,5-Trihydroxybenzoate;Kyselina gallova [Czech];Gallic acid polymer;Gallicum acidum;GALLIC ACID ANHYDROUS;Kyselina 3,4,5-trihydroxybenzoova [Czech];LNTHITQWFMADLM-UHFFF

Cas No.

149-91-7

分子式

C₇O₅H₆

分子量

170.12

包装储存

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2). Gallic acid has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities.

性状

Solid

IC50 & Target[1][2]

COX-2

Microbial Metabolite

Human Endogenous Metabolite

体外研究(In Vitro)

Gallic acid is an antioxidant which can inhibit both COX-2. After 18?h treatment with Gallic acid, the number of viable neutrophils is dramatically decreased from 40.3% to 27.7%, highly comparable with 26.4% for untreated neutrophils. Gallic acid fails to attenuate isoproterenol-induced myocytolysis.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

The food intake (2.6±0.08 g/day, p=0.69) and the body weight (2.5±0.69 g, p=0.76) of the Gallic acid group do not differ significantly from those of the control group (food intake; 2.41±0.14 g/day and the body weight; 2.83±0.84 g/day). The blood glucose tolerance in the Gallic acid group is significantly improved after 2 weeks of treatment. The blood glucose tolerance of the Gallic acid group after a treatment period of 2 weeks is also significantly better than that of the control group at 90 and 120 min ( p<0.05). The serum triglyceride concentration in the Gallic acid group (0.67±0.03 mM, p<0.05) is significantly reduced relative to that of the control group (1.08±0.20 mM). The total cholesterol concentration is similar in the control (3.19±0.27 mM) and Gallic acid (3.01±0.18 mM) groups.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

结构分类

来源

参考文献

[1]. Amaravani M, et al. COX-2 structural analysis and docking studies with gallic acid structural analogues. Springerplus. 2012 Dec;1(1):58. [Information]

[2]. Bak EJ, et al. Gallic acid improves glucose tolerance and triglyceride concentration in diet-induced obesity mice. Scand J Clin Lab Invest. 2013 Dec;73(8):607-14. [Information]

[3]. Cheng Y, et al. Plant Natural Products Calycosin and Gallic Acid Synergistically Attenuate Neutrophil Infiltration and Subsequent Injury in Isoproterenol-Induced Myocardial Infarction: A Possible Role for Leukotriene B4 12-Hydroxydehydrogenase? Oxid Med C [Information]

溶解度数据

体外研究:

DMSO : ≥ 100 mg/mL (587.82 mM)

H₂O : 8.33 mg/mL (48.97 mM; ultrasonic and warming and heat to 60°C)

* "≥" means soluble, but saturation unknown.

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.8782 mL	29.3910 mL	58.7820 mL
5 mM	1.1756 mL	5.8782 mL	11.7564 mL
10 mM	0.5878 mL	2.9391 mL	5.8782 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (14.70 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (14.70 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH?O 中，得到澄清透明的生理盐水溶液
2.

建议依照次序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (14.70 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (14.70 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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