Ranolazine 2HCl|95635-56-6|(盐酸雷诺嗪; CVT 303 dihydrochloride; RS 43285)-陌孚医药/Medlife

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Ranolazine 2HCl (Synonyms: 盐酸雷诺嗪; CVT 303 dihydrochloride; RS 43285)

目录号: PC11891 纯度: ≥98%

CAS No. :95635-56-6

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中文名称	Ranolazine 2HCl
中文别名	盐酸雷诺嗪;N-(2,6-二甲基苯基)-4-[2-羟基-3-(2-甲氧苯氧基)丙基]-1-哌嗪;乙酰胺盐酸盐;雷诺嗪;雷诺嗪及其盐;雷诺嗪二盐酸盐;雷诺嗪盐酸盐;3-氨基-4-(2-甲基丙胺基)喹啉N4-(2-甲基丙基)-3,4-喹啉二胺;N-(2,6-二甲基苯基)-2-(4-(2-羟基-3-(2-甲氧基苯氧基)-丙基)哌嗪-1-基)乙酰胺二盐酸盐;Ranolazine Dihydrochloride 雷诺嗪盐酸盐;二盐酸雷诺嗪;雷诺嗪二盐酸化物;雷诺嗪二盐酸盐标准品;N-(2,6-二甲基苯基)-4-[2-羟基-3-(2-甲氧苯氧基)丙基]-1-哌嗪乙酰胺;N-(2,6-二甲基苯基)-4-[2-羟基-3-(2-甲氧苯氧基)丙基]-1-哌嗪乙酰胺盐酸盐;雷喏嗪
英文名称	Ranolazine 2HCl
英文别名	N-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)acetamide dihydrochloride;(+/-)-4-[2-HYDROXY-3-(O-METHOXYPHENOXY)PROPYL]-1-PIPERAZINEACETO-2',6'-XYLIDIDE DIHYDROCHLORIDE;n-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide dihydrochloride;(+/-)-N-(2,6-DIMETHYLPHENYL)-4-[2-HYDROXY-3-(2-METHOXYPHENOXY)PROPYL]-1-PIPERAZINEACETAMIDE DIHYDROCHLORIDE;Ranolazine DiHCI;Ranolazine and salt;(±)-N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide;RANOLAZINE DI HCL;Ranolazine2Hcl;Ranolazine Dihydrochloride;N-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)-propyl)piperazin-1-yl)acetamide dihydrochloride;Ranolazine (hydrochloride);Ranolazine Dihydrocloride;Ranolazine HCl;Ranolazine dihydrochloride;RS 43285;Ranolazine (dihydrochloride);Ranolazine dihydroch;RS-43285;(±) -4-[2-Hydroxy-3-(o-methoxyphenoxy)propyl]-1-piperazineaceto-2′,6′-xylidide dihydrochloride;N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide dihydrochloride;Ranolazine 2HCl;Ranolazine hydrochloride;renolazine;Ranolazine hydrochloride [USAN];(+-)-4-(2-Hydroxy-3-(o-methoxyphenoxy)propyl)-1-piperazineaceto-2',6'-xylidide dihydrochl
Cas No.	95635-56-6
分子式	C₂₄H₃₅Cl₂N₃O₄
分子量	500.46
包装储存	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性

Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (I_Na and I_Kr with IC₅₀ values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP). Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor.

性状

Solid

IC50 & Target[1][2]

IC50: 6 μM (I_Na), 12 μM (I_Kr)

体内研究(In Vivo)

Ranolazine (Bolus injection 10 mg/kg and infusion 9.6 mg/kg/h; bolus injection; for 145 minutes; male Wistar rats) treatment significantly reduces infarct size and cardiac troponin T release in rats subjected to left anterior descending coronary artery occlusion-reperfusion.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (240-350 g)
Dosage:	Bolus injection 10 mg/kg and infusion (9.6 mg/kg/h)
Administration:	Bolus injection; for 145 minutes
Result:	Significantly reduced infarct size and cardiac troponin T release in rats subjected to left anterior descending coronary artery occlusion-reperfusion.

运输条件

Room temperature or refrigerated transportation.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Keating GM. Ranolazine: A Review of Its Use as Add-On Therapy in Patients with Chronic Stable Angina Pectoris. Drugs. 2013 Jan;73(1):55-73. [Information]

[2]. Wang WQ, Robertson C, Dhalla AK, Belardinelli L. Antitorsadogenic effects of ({+/-})-N-(2,6-dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits. J Pharmacol Exp Ther. 2008 Jun;325(3):875-81. doi: 10. [Information]

[3]. Zacharowski K, Blackburn B, Thiemermann C. Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat. Eur J Pharmacol. 2001 Apr 20;418(1-2):105-10. [Information]

溶解度数据

体外研究:

DMSO : ≥ 50 mg/mL (99.91 mM)

H₂O : ≥ 50 mg/mL (99.91 mM)

* "≥" means soluble, but saturation unknown.

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9982 mL	9.9908 mL	19.9816 mL
5 mM	0.3996 mL	1.9982 mL	3.9963 mL
10 mM	0.1998 mL	0.9991 mL	1.9982 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： PBS
Solubility: 100 mg/mL (199.82 mM); Clear solution; Need ultrasonic

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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