Phenylacetylglycine is a gut microbial metabolite that can activate β2AR. Phenylacetylglycine protects against cardiac injury caused by ischemia/reperfusion.
性状
Solid
IC50 & Target[1][2]
β2 adrenoceptor
Microbial Metabolite
Human Endogenous Metabolite
体外研究(In Vitro)
Phenylacetylglycine (10-100 μM; 30 min before H/R injury) 减少新生小鼠心肌细胞 (NMCMs) 失氧 (H/R) 损伤诱导的凋亡,激活 Gαi 和 Gαs 信号通路。
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Significantly decreased the ratio of Bax/Bcl2 and cleaved-caspase 3 expression. Enhanced p-PI3K protein expression. cAMP levels were increased in the early stage and then gradually decreased.