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AM580

选择性RARα激动剂，AM580 是一种稳定的 retinobenzoic 衍生物，是 RARα 的激动剂。

目录号: PC14995 纯度: ≥98%

CAS No. :102121-60-8

商品编号	规格	价格	会员价
PC14995-10mg	10mg	¥980.00	请登录
PC14995-50mg	50mg	¥3537.80	请登录
PC14995-10mM (in 1mL DMSO)	10mM (in 1mL DMSO)	¥735.00	请登录

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中文名称	AM580
中文别名	4-[(5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基)甲酰氨基]苯甲酸;4-(5,5,8,8-四甲基-5,6,7,8-四氢化萘-2-甲酰氨基)苯甲酸
英文名称	AM580
英文别名	4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamido)benzoic acid;4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]benzoic acid;4-[[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]Benzoic acid;AM 580;Benzoic acid,4-[[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]-;CD437;Am-580;CD 336;NSC608001;4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid;ro40-6055;AM580 (CD336);4-(1,1,4,4-Tetramethyltetralin-6-ylcarbonylamino)benzoic acid;4-((5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl)aminobenz;benzoicacid,4-((5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbony;2-Naphthalenecarboxamide,5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-N-3-quinolinyl-;CD336;NSC 608001;Ro 40-6055;l)amino-;AM580;4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid;VZ5S5G9ZFZ;4-((5,6
Cas No.	102121-60-8
分子式	C₂₂H₂₅NO₃
分子量	351.44
包装储存	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

生物活性	AM580 (CD336) (GMP) is AM580 (HY-10475) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AM580 is a selective RARα agonist.
性状	Solid
体外研究(In Vitro)	AM580 (GMP) (0.05 μM) induces mouse embryonic fibroblasts (MEFs) convert into chemically induced pluripotent stem cells (CiPSCs) with the adding in stage I and stage II medium. AM580 (GMP) (0-10 μM; 4 d) induces SH-SY5Y cells develop into neuron-like cells. AM580 (GMP) shows powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. AM580 (GMP) (2.5 μM; 4 d) induces myeloid progenitors develop into neutrophils. Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature or refrigerated transportation.
储存方式	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Zhao T, et al. Single-Cell RNA-Seq Reveals Dynamic Early Embryonic-like Programs during Chemical Reprogramming. Cell Stem Cell. 2018 Jul 5;23(1):31-45.e7. [Information] [2]. Cai A, et al. Neuroblastoma SH-SY5Y Cell Differentiation to Mature Neuron by AM580 Treatment. Neurochem Res. 2022 [Information] [3]. Gianní M, et al. AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. Blood. 1996 Feb 15;87(4):1520-31. [Information] [4]. Brok-Volchanskaya VS, et al. Effective and Rapid Generation of Functional Neutrophils from Induced Pluripotent Stem Cells Using ETV2-Modified mRNA. Stem Cell Reports. 2019 Dec 10;13(6):1099-1110. [Information]

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