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Adenosine.

抗心律失常药，可使阵发性室上性心动过速转为窦性心律。用于和房室有关的室上心律失常。2.治疗心绞痛、心肌梗塞、冠脉功能不全、动脉硬化、原发性高血压、脑血管障碍、中风后遗症、进行性肌肉萎缩等。

目录号: PC10347 纯度: ≥98%

CAS No. :58-61-7

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PC10347-10mM (in 1mL DMSO)	10mM (in 1mL DMSO)	¥539.00	请登录

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中文名称

Adenosine.

中文别名

阿糖腺苷;9-beta-D-阿拉伯呋喃糖基腺嘌呤;9-Β-D-阿拉伯呋喃糖基腺嘌呤;9-Β-D-阿拉伯呋喃糖腺嘌呤；9-Β-D-ARABINOFURANOSYLADENINE MONOHYDRATE;腺嘌呤阿拉伯糖苷；ADENINE ARABINOSIDE;阿糖腺嘌吟;腺嘌吟阿拉伯糖苷;腺苷;腺嘌呤核苷;（腺苷）腺嘌呤核苷;（腺苷）腺嘌呤核苷,BR;（腺苷）腺嘌呤核苷,对照品;D-腺嘌呤核苷;腺苷对照品;阿糖腺苷；腺嘌呤核苷;阿糖腺苷标准品;四乙酰核糖;腺甘酸 EP标准品;腺苷 USP标准品;腺苷标准品;腺苷(标准品);腺苷；Adenosine;腺苷植物提取物,标准品,对照品；Adenosine,;腺嘌呤核苷(腺苷);9-beta-D-呋喃核糖基腺嘌呤;9-β-D-呋喃核糖基腺嘌呤;腺甙;腺苷；腺尿环核苷；腺嘌呤核苷;腺苷；阿糖腺苷;腺呤配糖;腺尿环核苷;腺嘌呤核苷；腺苷;腺素苷;胰苷;腺嘌呤-9-β-D-呋喃核糖苷;阿糖腺苷,医药级,纯度:>99%;腺昔

英文名称

Adenosine

英文别名

Adenosine;ARABINOSYL-ADENINE;6-AMINO-9-BETA-D-ARABINOFURANOSYLPURINE;ADENINE-BETA-D-ARABINOFURANOSIDE;ADENINE-9-BETA-D-ARABINOFURANOSIDE;9-BETA-D-ARABINOSYLADENINE;9-BETA-D-ARABINOFURANOSYLADENINE;2'-ARAADENOSINE;SPONGOADENOSINE;(2R,3R,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol;ADENOSINE(RG);ADENOSINE FREE BASE;9-beta-D-Ribofuranosyladenine;9-β-D-Ribofuranosyladenine;Adenine riboside;Adenine-9-beta-D-ribofuranoside;Adenocor;Adenosin;Adesine;Adrekar;Boniton;D-Adenosine;Myocol;Sandesin;[ "" ];Adenoscan;Adenocard;beta-D-Adenosine;Nucleocardyl;Adenine nucleoside;beta-Adenosine;9-beta-D-Ribofuranosidoadenine;Adenosin [German];9-beta-D-Ribofuranosyl-9H-purin-6-amine;9beta-D-Ribofuranosyladenine;Ade-Rib;6-Amino-9-beta-D-ribofuranosyl-9H-purine;Pallacor;Caswell No. 010B;Adenosine [USAN:BAN];beta-D-Ribofuranoside, adenine-9;6-Amino-9beta-D-ribofuranosyl-9H-purine;(2R,3R,4S,5

Cas No.

58-61-7

分子式

C₁₀H₁₃N₅O₄

分子量

267.24

包装储存

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.

性状

Solid

IC50 & Target[1][2]

Human Endogenous Metabolite

Microbial Metabolite

体外研究(In Vitro)

Adenosine (Adenine riboside) acts on four G-protein coupled receptors: two of them, A1 and A3, are primarily coupled to Gi family G proteins; and two of them, A2A and A2B, are mostly coupled to Gs like G proteins. These receptors are antagonized by xanthines including caffeine. Via these receptors it affects many cells and organs, usually having a cytoprotective function.
Adenosine is an extracellular signaling molecule that is generated from its precursor molecules 5’-adenosine triphosphate (ATP) and 5’-adenosine monophosphate (AMP).
Adenosine is a common metabolite of ATP, which exhibits cytotoxic effects at high concentrations.Adenosine (1.0-4.0 mM; 12-24 hours) inhibits cell viability and triggers ER stress in HepG2 cells.
Adenosine induces apoptosis in a variety of cancer cells. Adenosine (2.0 mM; 12-24 hours) induces autophagy in HepG2 cells. In HepG2 cell lines, Adenosine -induced AMPK/mTOR pathway activation partially blocked ER stress and decreased apoptotic cell death.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

ClinicalTrial

结构分类

Others

参考文献

[1]. Fredholm BB. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ. 2007;14(7):1315-1323. [Information]

[2]. Borea PA, Gessi S, Merighi S, Vincenzi F, Varani K. Pharmacology of Adenosine Receptors: The State of the Art. Physiol Rev. 2018;98(3):1591-1625. [Information]

[3]. Eltzschig HK. Adenosine: an old drug newly discovered. Anesthesiology. 2009;111(4):904-915. [Information]

[4]. Zhou XT, et al. Inhibition of autophagy enhances adenosine induced apoptosis in human hepatoblastoma HepG2 cells. Oncol Rep. 2019;41(2):829-838. [Information]

溶解度数据

体外研究:

DMSO : 33.33 mg/mL (124.72 mM; Need ultrasonic)

H₂O : ≥ 6.67 mg/mL (24.96 mM)

* "≥" means soluble, but saturation unknown.

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.7420 mL	18.7098 mL	37.4195 mL
5 mM	0.7484 mL	3.7420 mL	7.4839 mL
10 mM	0.3742 mL	1.8710 mL	3.7420 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： PBS
Solubility: 6.67 mg/mL (24.96 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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