14325-05-4|Tin protoporphyrin IX dichloride，≥98%|Medlife|Medlife为MCE，Selleck，麦克林，阿拉丁试剂，罗恩试剂，Sigma，安耐吉试剂，泰坦等同类产品品牌，上海现货，高性价比小分子化合物

您当前的位置：

Tin protoporphyrin IX dichloride

血红素加氧酶抑制剂，Tin-protoporphyrin IX (SnPPIX) 是有效的血红素加氧酶-1 (HO-1) 抑制剂。 Tin-protoporphyrin IX (SnPPIX) 使 PDAC 管腺癌肿瘤对化疗敏感。

目录号: PC15159 纯度: ≥98%

CAS No. :14325-05-4

商品编号	规格	价格	会员价
PC15159-10mg	10mg	¥1342.60	请登录
PC15159-25mg	25mg	¥3184.02	请登录
PC15159-50mg	50mg	¥5638.92	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Tin protoporphyrin IX dichloride
中文别名	锡原卟啉IX二氯乙烷;原卟啉二氯化锡(IV);锡(IV) 卟啉 IX 二氯
英文名称	Tin protoporphyrin IX dichloride
英文别名	Stannate(2-),dichloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kN21,kN22,kN23,kN24]-, hydrogen (1:2), (OC-6-13)-;Stannate(2-),dichloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kN21,kN22,kN23,kN24]-, hydr;Tin Protoporphyrin IX (chloride);TIN PROTOPORPHYRIN IX DICHLORIDE;Sn(IV) Protoporphyrin IX dichloride;tin protophorphyrin;Stannate(2-) dichloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid];Nsc267099;TINPROTOPORPHYRIN;tin protoporphyrin IX;Tin-protoporphyrin IX
Cas No.	14325-05-4
分子式	C₃₄H₃₂N₄O₄Sn
分子量	679.35
包装储存	Sealed and stored at -20℃, moisture-proof *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性

Tin-protoporphyrin IX (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin-protoporphyrin IX (SnPPIX) sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model.

性状

Solid

IC50 & Target[1][2]

IC50: Heme oxygenase-1 (HO-1)

体外研究(In Vitro)

Tin-protoporphyrin IX (SnPPIX)(20 μM, 50 μM; 24 hours) significantly suppressed the proliferation of Capan-1 and CD18/HPAF cells. In contrast, SnPPIX has no significant effect on PDAC cells proliferation at all exposures except at 50 μM.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	Capan-1, CD18/HPAF, PDAC cells
Concentration:	20 μM, 50 μM
Incubation Time:	24 or 72 hours
Result:	Inhibited Capan-1 and CD18/HPAF cells proliferation and inhibits PDAC cells growth at 50μM.

体内研究(In Vivo)

Tin-protoporphyrin IX (SnPPIX)(intraperitoneal injection; 5 mg/kg; at 0, 7, 15, and 20 days) alone or combines with Gemcitabine significantly reduced the weight of pancreatic tumors (P < 0.05), decreases metastasis and improved the efficacy of Gemcitabine treatment.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male and female athymic nude mice with PDAC cell-derived xenograft tumors
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; at days 1, 4, 6, 8, 11, 13, 15, 18, and 20
Result:	Inhibited tumor growth and sensitized tumors to chemotherapy (Gemcitabine).

运输条件

Room temperature or refrigerated transportation.

储存方式

Sealed and stored at -20℃, moisture-proof

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献

[1]. Abdalla MY,et al.Enhancing responsiveness of pancreatic cancer cells to gemcitabine treatment under hypoxia by heme oxygenase-1 inhibition.Transl Res. 2019 May;207:56-69. [Information]

溶解度数据

体外研究:

0.1 M NaOH : 14.29 mg/mL (19.05 mM; ultrasonic and adjust pH to 12 with NaOH)

DMF : 1 mg/mL (1.33 mM; Need ultrasonic and warming)

DMSO : 0.5 mg/mL (0.67 mM; Need ultrasonic and warming)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.3329 mL	6.6644 mL	13.3287 mL
5 mM	0.2666 mL	1.3329 mL	2.6657 mL
10 mM	0.1333 mL	0.6664 mL	1.3329 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation