RS 100329 hydrochloride|1215654-26-4|-陌孚医药/Medlife

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RS 100329 hydrochloride

目录号: PC10826 纯度: ≥98%

CAS No. :1215654-26-4

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中文名称	RS 100329 hydrochloride
中文别名	RS 100329 hydrochloride
英文名称	RS 100329 hydrochloride
英文别名	RS 100329 hydrochloride;5-METHYL-3-[3-[3-[4-[2-(2,2,2-TRIFLUOROETHOXY)PHENYL]-1-PIPERAZINYL]PROPYL]-2,4-(1H,3H)-PYRIMIDINEDIONE] HYDROCHLORIDE;5-methyl-3-(3-(4-(2-(2,2,2-trifluoroethoxy)phenyl)piperazin-1-yl)propyl)pyrimidine-2,4(1H,3H)-dione hydrochloride;5-Methyl-3-[3-[3-[4-[2-(2,2,2-trifluoroethoxy)phenyl]-1-piperazinyl] propyl]-2,4-(1H,3H)-pyrimidinedione] hydrochloride;5-Methyl-3-[3-[3-[
Cas No.	1215654-26-4
分子式	C₂₀H₂₆ClF₃N₄O₃
分子量	462.89
包装储存	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

生物活性

RS100329 hydrochloride is a potent and selective α1A-adrenoceptor antagonist with pK_i values of 9.6, 7.9 and 7.5 for α1A, α1D, and α1B, respectively. RS100329 hydrochloride inhibits reflex urethral contractions. RS100329 hydrochloride can be used in research of benign prostatic hyperplasia.

性状

Solid

IC50 & Target[1][2]

pKi: 9.6 (α1A-adrenoceptor), 7.9 (α1D-adrenoceptor) and 7.5 (α1B-adrenoceptor)

体外研究(In Vitro)

RS100329 hydrochloride (human lower urinary tract (LUT) tissues) contractions to Norepinephrine (HY-13715) is antagonized in a surmountable and concentration-dependent manner.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

RS100329 hydrochloride (0.01-0.1 mg/kg; i.v.; Sprague Dawley rats) reduces baseline urethral pressure and inhibit reflex urethral contractions.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague Dawley rats (300-390 g)
Dosage:	0.01-0.1 mg/kg
Administration:	Intravenous injection
Result:	Caused a fall in baseline urethral pressure reaching a maximum of 23%.

运输条件

Room temperature or refrigerated transportation.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献

[1]. Conley RK, et, al. The role of alpha(1)-adrenoceptors and 5-HT(1A) receptors in the control of the micturition reflex in male anaesthetized rats. Br J Pharmacol. 2001 May;133(1):61-72. [Information]

[2]. Williams TJ, et, al. 体外研究 alpha1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel alpha1A-adrenoceptor selective antagonists. Br J Pharmacol. 1999 May;127(1):252-8. [Information]

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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