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HPI 1

Hh信号传导抑制剂,HPI-1 is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Shh (IC50=1.5 uM) without significantly affecting Wnt signaling (IC50>30 uM).

目录号: PC15843 纯度: ≥94%

CAS No. :599150-20-6

商品编号	规格	价格	会员价	是否有货	数量
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中文名称

HPI 1

英文名称

HPI 1

英文别名

2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin;2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline;HPI 1;HPI-1;0130970;2-METHOXYETHYL 1,4,5,6,7,8-HEXAHYDRO-4-(3-HYDROXYPHENYL)-7-(2-METHOXYPHENYL)-2-METHYL-5-OXO-3-QUINOLINECARBOXYLATE;A3094;AC1MFWGY;CHEMBL1243339;MolPort-000-907-696;ST093553;STK403236;SureCN644336

Cas No.

599150-20-6

分子式

C₂₆H₂₉NO₄

分子量

419.51

包装储存

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

GLI antagonist-1 is a potent GLI antagonist with an IC₅₀ value of 1.1 μM. GLI antagonist-1 shows anti-proliferative activity. GLI antagonist-1 decreases the GLI1 mRNA expression. GLI antagonist-1 inhibits colony formation in a dose-dependent manner.

性状

Solid

IC50 & Target[1][2]

IC₅₀: 1.1 μM (GLI)

体外研究(In Vitro)

GLI antagonist-1 (compound HPI-1) (0-25 μM; 72 h) shows anti-proliferative activity with IC₅₀ values of 29, >25, 20.5 μM for SUM149, MDA-MB-231, SUM159 cells, respectively.
GLI antagonist-1 (10 μM; 72 h) decreases the GLI1 mRNA expression in SUM149 cells.
GLI antagonist-1 (5, 10, 20 μM) inhibits colony formation in a dose-dependent manner in SUM149 and MDA-MB-231 cells.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	SUM149, MDA-MB-231, SUM159 cells
Concentration:	0-25 μM
Incubation Time:	72 h
Result:	Showed anti-proliferative activity with IC₅₀ values of 29, >25, 20.5 μM for SUM149, MDA-MB-231, SUM159 cells, respectively.

运输条件

Room temperature or refrigerated transportation.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

[1]. Oladapo HO, et al. Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells. Cancer Lett. 2017 Dec 28;411:136-149. [Information]

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Data Sheet

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