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CGRP 8-37 (rat)

CGRP1受体的肽拮抗剂,Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) 是高度选择的 CGRP receptor 拮抗剂。

目录号: PC10811 纯度: ≥98%

CAS No. :129121-73-9

商品编号	规格	价格	会员价	是否有货	数量
PC10811-500ug	500ug	¥6487.60	请登录

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中文名称

CGRP 8-37 (rat)

中文别名

降钙素基因相关肽(8-37),大鼠

英文名称

CGRP 8-37 (rat)

英文别名

8-37-a-Calcitoningene-related peptide (human reduced), 25-L-aspartic acid-35-L-glutamic acid-;8-37-a-Calcitoningene-related peptide (rat reduced) (9CI);a-Calcitoningene-related peptide (human reduced),1-de-L-alanine-2-de-L-cysteine-3-de-L-asparticacid-4-de-L-threonine-5-de-L-alanine-6-de-L-threonine-7-de-L-cysteine-25-L-asparticacid-35-L-glutamic acid-;Rat CGRP-(8-37);Rat calcitoningene-related peptide-(8-37);ALA-CYS-ASP-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2: ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2DISULF;Calcitonin Gene Related Peptide (8-37), rat;CGRP 8-37 (rat);VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF;α-CGRP (8-37) (mouse, rat);α-CGRP (8-37) (mouse, rat), Calcitonin Gene-Related Peptide I (8-37) (mouse, rat), CGRP-I (8-37) (mo;Α-CGRP (8-37) (RAT);ALA-CYS-ASP-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2: ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2DISULFIDE BRIDGE CYS2-CYS7;ALPHA-CGRP (8-37) (RAT);H-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2;VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2;VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2;a-CGRP (8-37) (Mouse, rat);Alpha-CGRP (8-37) (mouse, rat);ALPHA-CALCITONIN GENE-RELATED PEPTIDE (8-37) (RAT);α-CGRP (8-37) (mouse, rat),Calcitonin Gene-Related Peptide I (8-37) (mouse, rat), CGRP-I (8-37) (mouse, rat)

Cas No.

129121-73-9

分子式

C₁₃₈H₂₂₄N₄₂O₄₁

分子量

3127.51

包装储存

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

生物活性

Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist.

性状

Solid

IC50 & Target[1][2]

CGRP receptor

体外研究(In Vitro)

CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

CGRP-(8-37) is effective in alleviating mechanical and thermal allodynia in a dose-dependent manner. The 50 nM dose is most efficacious for both forelimb and hindlimb responses. The period of efficacy is 10 min to onset for a duration of 20 min. Post-drug washout responses are not statistically significant compared to pre-drug responses. Intrathecal administration of 5 nmol or 10 nmol of CGRP-(8-37), but not 1 nmol, induces a significant increase in hindpaw withdrawal latency. Intrathecal administration of CGRP-(8-37) not only reverses the SP-induced decrease in latency to both withdrawal responses but also mediates a significant increase in response latency compared to basal levels.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

SequenceShortening

VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2

Sequence

Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2

参考文献

[1]. Bennett AD, et al. Alleviation of mechanical and thermal allodynia by CGRP(8-37) in a rodent model of chroniccentral pain. Pain. 2000 May;86(1-2):163-75. [Information]

[2]. Yu LC, et al. The calcitonin gene-related peptide antagonist CGRP8-37 increases the latency to withdrawalresponses in rats. Brain Res. 1994 Aug 8;653(1-2):223-30. [Information]

溶解度数据

体外研究:

H₂O : 25 mg/mL (7.99 mM; Need ultrasonic)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.3197 mL	1.5987 mL	3.1974 mL
5 mM	0.0639 mL	0.3197 mL	0.6395 mL
10 mM	---	---	---

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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