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Ciglitazone

PPARγ激动剂，Ciglitazone is a PPARγ agonist. It is known to decrease insulin levels, VEGF production and blood pressure and induces cell cycle arrest in stomach cancer cells.

目录号: PC12641 纯度: ≥98%

CAS No. :74772-77-3

商品编号	规格	价格	会员价	是否有货	数量
PC12641-10mg	10mg	¥4096.40	请登录
PC12641-50mg	50mg	¥16856.00	请登录

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中文名称

Ciglitazone

中文别名

环格列酮;酪里达唑;5-[[4-[(1-甲基环己基)甲氧基]苯基]甲基]-2,4-噻唑烷二酮

英文名称

Ciglitazone

英文别名

2,4-Thiazolidinedione,5-[[4-[(1-methylcyclohexyl)methoxy]phenyl]methyl]-;Ciglitazone;Ciglitazone（U-63287,ADD 3878）;Ciglitazone,5-[[4-[(1-Methylcyclohexyl)methoxy]phenyl]methyl]-2,4-thiazolidinedione;(±)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione;AD-4533;ADD 3878;CIGLITIZONE;CIGLITLZONE;Flurofamide;U 63287;Ciglitazona;Ciglitazonum;Ciglitazonum [Latin];Ciglitazona [Spanish];Ciglitazone [USAN:INN];5-(4-((1-methylcyclohexyl)methoxy)benzyl)thiazolidine-2,4-dione;(+-)-5-(p-((1-Methylcyclohexyl)methoxy)benzyl)-2,4-thiazolidinedione;C18H23NO3S;YZFWTZACSRHJQD-UHFFFAOYSA-N;5-{4-[(1-methylcyclohexyl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione;(+/-)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione;NCGC00

Cas No.

74772-77-3

分子式

C₁₈H₂₃NO₃S

分子量

333.45

包装储存

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

Ciglitazone is a potent and selective PPARγ agonist (EC₅₀=3 μM). Ciglitazone inhibits proliferation and differentiation of th17 cells. Ciglitazone is a hypoglycemic agent orally active in the obese-hyperglycemic animal models. Ciglitazone induces apoptosis accompanied by activation of p38 MAPK and nuclear translocation of apoptosis inducing factor (AIF) in opossum kidney (OK) renal epithelial cells.

性状

Solid

体外研究(In Vitro)

Ciglitazone (0-20 μM; 24 hours) induces apoptosis through PPAR-independent mechanism. Ciglitazone causes generation of ROS and an increase in intracellular Ca.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

In C57BL/6J-ob/ob mice, Ciglitazone (100 mg/kg/day; 2 days) elicits a drastic fall in blood glucose. Regranulation of islet beta-cells and increased pancreatic insulin content are observed in ob/ob mice treated for 41-44 days with 100 mg/kg/day Ciglitazone.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

[1]. Willson TM, et al. The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. J Med Chem. 1996;39(3):665-668. [Information]

[2]. Kim DH, et al. Ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, inhibits proliferation and differentiation of th17 cells. Biomol Ther (Seoul). 2015;23(1):71-76. [Information]

[3]. Chang AY, et al. Ciglitazone, a new hypoglycemic agent. I. Studies in ob/ob and db/db mice, diabetic Chinese hamsters, and normal and streptozotocin-diabetic rats. Diabetes. 1983;32(9):830-838. [Information]

[4]. Kwon CH, et al. Ciglitazone induces apoptosis via activation of p38 MAPK and AIF nuclear translocation mediated by reactive oxygen species and Ca(2+) in opossum kidney cells. Toxicology. 2009;257(1-2):1-9. [Information]

溶解度数据

体外研究:

DMSO : 100 mg/mL (299.90 mM; Need ultrasonic)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.9990 mL	14.9948 mL	29.9895 mL
5 mM	0.5998 mL	2.9990 mL	5.9979 mL
10 mM	0.2999 mL	1.4995 mL	2.9990 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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