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Leucovorin Calcium.

叶酸的衍生物,Folinic Acid是还原的叶酸，可与其它化疗药结合使用。

目录号: PC12445 纯度: ≥98%

CAS No. :6035-45-6

商品编号	规格	价格	会员价	是否有货	数量
PC12445-25mg	25mg	¥441.00	请登录
PC12445-10mM (in 1mL H2O)	10mM (in 1mL H2O)	¥490.00	请登录

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中文名称	Leucovorin Calcium.
中文别名	亚叶酸钙;N-[4-[(2-氨基-5-甲酰基-4-氧代-1,6,7,8-四氢-6-蝶啶基)甲基]氨基]苯甲酰基-L-谷氨酸钙盐;亚叶酸钙五水合物;1,4-双(4-苯氧苯酰基)苯;亚叶酸, 钙盐;亚叶酸钙工厂
英文名称	Leucovorin Calcium
英文别名	Calcium folinatc;Folinic acid calcium salt;Calcium (2S)-2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate;Leucovorin Calcium Salt Pentahydrate;Folinic Acid Calcium Pentahydrate;Calcium folinate;Folinic acid (calcium salt pentahydrate);Leucovorin Calcium;Leucovorin calcium pentahydrate;alcium folinatc;(6S)-calcium folinate;5-formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt;CALCIUM FOLINATE(FOLINIC ACID)(RG);Folaren;Foliben;Folidan;FOLINIC ACID CALCIUM CELL CULTURE TESTED;FOLINIC ACID(SEE CALCIUM FOLINATE);Leucovorin 30(R);Folinic Acid, Calcium Salt Pentahydrate;Folinic acid calcium salt pentahydrate
Cas No.	6035-45-6
分子式	C₂₀H₂₁CaN₇O₇
分子量	511.50
包装储存	Sealed and stored at 4℃, moisture-proof and light proof *该产品在溶液状态不稳定，建议您现用现配，即刻使用。

生物活性

Folinic acid calcium salt pentahydrate (Leucovorin calcium salt pentahydrate) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity.

性状

Solid

IC50 & Target[1][2]

Human Endogenous Metabolite

体外研究(In Vitro)

MTX alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) .

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice).

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)
Dosage:	7.0 mg/kg
Administration:	Intraperitoneal injection; every second day; for 3 weeks
Result:	Following methotrexate (MTX) administration appears to reverse this growth inhibition.

运输条件

Room temperature or refrigerated transportation.

储存方式

Sealed and stored at 4℃, moisture-proof and light proof

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

ClinicalTrial

参考文献

[1]. Keshava C, et al. Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res. 1998 Feb 2;397(2):221-8. [Information]

[2]. Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44. [Information]

溶解度数据

体外研究:

H₂O : 10 mg/mL (16.62 mM; Need ultrasonic)

DMSO : 1 mg/mL (1.66 mM; ultrasonic and warming and heat to 80°C)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.6623 mL	8.3114 mL	16.6229 mL
5 mM	0.3325 mL	1.6623 mL	3.3246 mL
10 mM	0.1662 mL	0.8311 mL	1.6623 mL

建议根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备溶液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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