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Zinc protoporphyrin IX

血红素加氧酶抑制剂，inc Protoporphyrin (Zn(II)-protoporphyrin IX) 是一种竞争性的血红素加氧酶-1 (HO-1) 抑制剂，显着减弱间苯三酚 (PG) 对 H2O2 的保护作用。Zinc Protoporphyrin 是在血红素生物合成期间以痕量形成的正常代谢物，可用作个体孕妇和儿童缺铁的筛查标志物，也用于评估人群铁状态与血红蛋白浓度的组合。

目录号: PC15158 纯度: ≥98%

CAS No. :15442-64-5

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中文名称	Zinc protoporphyrin IX
中文别名	三水合原卟啉锌;丙酸锌;胆甾醇基氢琥珀酸盐;锌原卟啉;原卟啉锌;3,7,12,17-四甲基-8,13-二乙烯基-2,18-卟吩二丙酸;原卟啉 IX 锌(II) 络合物
英文名称	Zinc protoporphyrin IX
英文别名	Zinc protoporphyrin;Zinc protoporphyrin IX;Zinc Protoporphyrin-9;ZINC(II) PROTOPORPHYRIN;Protoporphyrin IX zinc(II);PROTOPORPHYRINATO ZINC;zinc,3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;8,13-Divinyl-3,7,12,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid zinc derivative
Cas No.	15442-64-5
分子式	C₃₄H₃₂N₄O₄-₂^.Zn+₂
分子量	626.03
包装储存	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性

Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H₂O₂. Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration. Zinc Protoporphyrin has anti-cancer activity.

性状

Solid

IC50 & Target[1][2]

Human Endogenous Metabolite

体外研究(In Vitro)

Zinc Protoporphyrin (Zn(II)-protoporphyrin IX; 5 μM; 72 hours) causes the fraction of late apoptotic and necrotic cells increasing from 10.9% in controls to 30.4% after 72 h.
Zinc Protoporphyrin (1.25-40 μM; 48 or 72 hours) exerts cystostatic/cytotoxic effects against tumor cells.
Zinc Protoporphyrin (2.5, 5 μM; 48 or 72 hours) results in dose- and time-dependent reduction of cells in G1 phase of the cell cycle.
Zinc Protoporphyrin (1.25-40 μM; 48 hours) leads to accumulation of cleaved (active) caspase-3.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis

Cell Line:	C-26 cells
Concentration:	5 μM
Incubation Time:	72 hours
Result:	The fraction of late apoptotic and necrotic cells increased from 10.9% in controls to 30.4% after 72 h.

Cell Cytotoxicity Assay

Cell Line:	C-26 and MDA-MB231 cells
Concentration:	1.25, 2.5, 5, 10, 20, 40 μM
Incubation Time:	48 or 72 hours
Result:	Exerted cystostatic/cytotoxic effects against tumor cells.

Cell Cycle Analysis

Cell Line:	C-26 cells
Concentration:	2.5, 5 μM
Incubation Time:	48 or 72 hours
Result:	Resulted in dose- and time-dependent reduction of cells in G1 phase of the cell cycle.

Western Blot Analysis

Cell Line:	C-26 cells
Concentration:	1.25, 2.5, 5, 10, 20, 40 μM
Incubation Time:	48 hours
Result:	Leaded to accumulation of cleaved (active) caspase-3.

体内研究(In Vivo)

Zinc Protoporphyrin (12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o.; from day 7 to 19) exerts dose-dependent antitumor effects manifested by the retardation of tumor growth.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c mice inoculated with C-26 cells
Dosage:	12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o.
Administration:	IP or PO; from day 7 to 19
Result:	Exerted dose-dependent antitumor effects manifested by the retardation of tumor growth.

运输条件

Room temperature or refrigerated transportation.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献

[1]. Park C, et al. Protective Effect of Phloroglucinol on Oxidative Stress-Induced DNA Damage and Apoptosisthrough Activation of the Nrf2/HO-1 Signaling Pathway in HaCaT Human Keratinocytes. Mar Drugs. 2019 Apr 13;17(4). [Information]

[2]. Mwangi MN, et al. Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan pregnant women. BMC Med. 2014 Nov 26;12:229. [Information]

[3]. Nowis D, et al. Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice. BMC Cancer. 2008 Jul 11;8:197. [Information]

溶解度数据

体外研究:

DMSO : 20.83 mg/mL (33.27 mM; ultrasonic and warming and heat to 80°C)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.5974 mL	7.9870 mL	15.9739 mL
5 mM	0.3195 mL	1.5974 mL	3.1948 mL
10 mM	0.1597 mL	0.7987 mL	1.5974 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： 50% PEG300 50% saline
Solubility: 1.67 mg/mL (2.67 mM); Suspended solution; Need ultrasonic

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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