10083-24-6|Piceatannol，≥98%|Medlife|Medlife为MCE，Selleck，麦克林，阿拉丁试剂，罗恩试剂，Sigma，安耐吉试剂，泰坦等同类产品品牌，上海现货，高性价比小分子化合物

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Piceatannol

p56lck/Syk抑制剂，Piceatannol是蛋白质酪氨酸激酶Syk的选择性抑制剂，它能够抑制ICa,L, Ito, IKr，Ca2+转移和除了IK1的Na+-Ca2+交换。

目录号: PC11622 纯度: ≥98%

CAS No. :10083-24-6

商品编号	规格	价格	会员价	是否有货	数量
PC11622-20mg	20mg	¥1038.80	请登录
PC11622-10mM (in 1mL DMSO)	10mM (in 1mL DMSO)	¥715.40	请登录

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中文名称

Piceatannol

中文别名

白皮杉醇;(E)-4-[2-(3,5-二羟基苯)乙烯基]-1,2-苯二酚;3,4,3',5'-四羟基-反式-二苯乙烯;比杉特醇;(E)-3,3',4,5'-四羟基苯乙烯;3'-羟基白藜芦醇;4-[2-(3,5-二羟基苯基)乙烯基]-1,2-苯二酚;Piceatannol 白皮杉醇;白皮杉醇；比杉特醇;比杉特醇；Piceatannol

英文名称

Piceatannol

英文别名

trans-Piceatannol;TRANS-3,3',4,5'-TETRAHYDROXYSTILBENE;PICEATANNOL;(e)-4-[2-(3,5dihydroxyphenyl)ethenyl]1,2-benzenediol;4-[2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol;(E)-3,3',4,5'-Tetrahydroxystilbene;(E)-Piceatannol;Astringenin;(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol;3,3',4,5'-Tetrahydroxy-trans-stilbene;3,3′,4,5′-Stilbenetetrol;3,3′,4,5′-Tetrahydroxy-trans-stilbene;3,4,3',5'-Tetrahydroxy-trans-stilbene;3;3-Hydroxyresveratol;astringinin;piceatanol;3,5,3',4'-Tetrahydroxystilbene;3,3',4'5-Tetrahydroxystilbene;4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol;3,3',4,5'-Tetrahydroxystilbene;6KS3LS0D4F;3,3',4,5'-Stilbenetetrol;4-[(E)-2-(3,5-dihydroxyphenyl)vinyl]benzene-1,2-diol;1,2-Benzenediol, 4-(2-(3,5-dihydroxyphenyl)ethenyl)-, (E)-;C14H12O4;NSC365798;MFC

Cas No.

10083-24-6

分子式

C₁₄H₁₂O₄

分子量

244.24

包装储存

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

Piceatannol is a well-known Syk inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI). Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties. Piceatannol induces apoptosis in DLBCL cell lines. Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells.

性状

Solid

体外研究(In Vitro)

Piceatannol is a resveratrol metabolite.
SYK inhibitor Piceatannol (3.125, 6.25, 12.5, 25, and 50 μM; 72 hours) inhibits cell growth of six diffuse large B cell lymphomas (DLBCL) cell lines (SUDHL-6, U2392,DOHH2,Karpas 422, VAL, OCI Ly19) with IC₅₀s of 18 μM, 25 μM, 37 μM, 48 μM, >50 μM and >50 μM, respectively.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay

Cell Line:	Six DLBCL cell lines (Karpas 422, VAL, SUDHL-6, OCI Ly19, U2392 and DOHH2)
Concentration:	3.125, 6.25, 12.5, 25, and 50 μM
Incubation Time:	72 hours
Result:	The IC₅₀s were 18 μM in SUDHL-6, 25 μM in U2392, 37 mM in DOHH2, 48 μM in Karpas 422 and higher than 50 μM in OCI-Ly19 and in VAL.

体内研究(In Vivo)

Piceatannol (10, 20, and 40 mg/kg) inhibits the pulmonary edema and reduces the infiltration of inflammatory cells induced by lipopolysaccharide.
Piceatannol (10, 20, and 40 mg/kg) alleviates the myeloperoxidase activity and inhibits the production of iNOS and COX-2 expressions in lung tissuesinduced by lipopolysaccharide.
Piceatannol (10, 20, and 40 mg/kg; intraperitoneally 1 h) treatment alleviates inflammatory response by inhibiting the activation of TLR/NF-κB signaling pathway in lung tissues during acute lung injury (ALI) induced by LPS.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6 mice (40-50 g)
Dosage:	10, 20, and 40 mg/kg
Administration:	Intraperitoneally 1 h before LPS challenge
Result:	Significantly reduced the pulmonary edema induced by LPS.

运输条件

Room temperature or refrigerated transportation.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

结构分类

Stilbenes

来源

参考文献

[1]. Lu-Yuan Peng,et al. Protective Effect of Piceatannol Against Acute Lung Injury Through Protecting the Integrity of Air-Blood Barrier and Modulating the TLR4/NF-κB Signaling Pathway Activation. Front Pharmacol. 2020 Jan 22;10:1613. [Information]

[2]. Jonathan Kershaw, et al. The Therapeutic Potential of Piceatannol, a Natural Stilbene, in Metabolic Diseases: A Review. J Med Food. 2017 May;20(5):427-438. [Information]

[3]. Andrea Rinaldi, et al. 体外研究 efficacy of tyrosine kinase inhibitors: SYK and BCR-ABL inhibitors in lymphomas.Hematol Oncol. 2011 Sep;29(3):164-6. [Information]

[4]. Kamila Siedlecka-Kroplewska, et al. Induction of autophagy, apoptosis and aquisition of resistance in response to piceatannol toxicity in MOLT-4 human leukemia cells. Toxicol 体外研究. 2019 Sep;59:12-25. [Information]

溶解度数据

体外研究:

DMSO : ≥ 31 mg/mL (126.92 mM)

H₂O : 1 mg/mL (4.09 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.0943 mL	20.4717 mL	40.9433 mL
5 mM	0.8189 mL	4.0943 mL	8.1887 mL
10 mM	0.4094 mL	2.0472 mL	4.0943 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (10.24 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (10.24 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH?O 中，得到澄清透明的生理盐水溶液
2.

建议依照次序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (10.24 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (10.24 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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