HLE抑制剂,High affinity, potent inhibitor of human leukocyte elastase (HLE) (IC50 = 3.9 nM). Displays species-selectivity (Ki values are 0.017, 1.70, 3.01, 58 and > 100 nM?for human, mouse, rat, rabbit and porcine elastase respectively).
SSR 69071;4H-Pyrido[1,2-a]pyrimidin-4-one, 2-[[6-methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-;6-methoxy-1,1-dioxo-2-[[4-oxo-9-(2-piperidin-1-ylethoxy)pyrido[1,2-a]pyrimidin-2-yl]oxymethyl]-4-propan-2-yl-1,2-benzothiazol-3-one;2-[[6-Methoxy-4-(1-Methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]Methoxy]-9-[2-(1-piperidinyl)ethoxy]-4H-pyrido[1,2-a]pyriMidin-4-one;HMS3269M07