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L-NAME hydrochloride.

NO合酶抑制剂，L-NAME hydrochloride是 NOS 的抑制剂，IC50 为70 μM。

目录号: PC14820 纯度: ≥98%

CAS No. :51298-62-5

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中文名称	L-NAME hydrochloride.
中文别名	N'-硝基-L-精氨酸甲酯盐酸盐;N-硝基-L-精氨酸甲酯;N(ω)-硝基-L-精氨酸甲酯盐酸盐;N-硝基-L-精氨酸甲酯盐酸盐;NG-硝基-L-精氨酸甲基酯盐酸盐;NG-硝基-L-精氨酸甲酯盐酸盐;Nomega-Nitro-L-arginine Methyl Ester Hydrochloride N(ω)-硝基-L-精氨酸甲酯盐酸盐;Nω-硝基-L-精氨酸甲酯盐酸盐;N-硝基-L-精氨酸甲基酯盐酸盐;N''-硝基-L-精氨酸甲酯盐酸盐;一氧化氮合酶抑制剂;N’-硝基-L-精氨酸甲酯盐酸盐;精氨酸硝基盐酸盐
英文名称	Methyl N5-(imino(nitroamino)methyl)-L-ornithine monohydrochloride
英文别名	(S)-Methyl 2-amino-5-(3-nitroguanidino)pentanoate hydrochloride;H-Arg(NOZ)-OMe.HCl;L-NAME hydrochloride;N'-Nitro-L-arginine methyl ester hydrochloride;Nomega-Nitro-L-arginine Methyl Ester Hydrochloride;L-NAME;(S)-Methyl 2-amino-5-(3-nitroguanidino)-pentanoate hydrochloride;H-Arg(NO?)-OMe·HCl;H-Arg(NO₂)-OMe · HCl;H-Arg(NO2)-OMe.HCl;H-Arg(NO2)-OMe·HCl;H-Arg(NO2)-OMe·HClN-ω-Nitro-L-arginine methyl ester hydrochloride;H-Arg(NO2)-OMe•HCl;L-NAME (hydrochloride);L-NAME,BR;methyl (2S)-2-amino-5-[[amino(nitramido)methylidene]amino]pentanoate,hydrochloride;NG-Nitroarginine methyl ester hydrochloride;Nitroarginine Methyl;Nitroarginine Methyl Ester Hydrochloride;N'-Nitro-L-arginine-methyl ester hydrochloride;N-ω-Nitro-L-arginine methyl ester hydrochloride;Nω-Nitro-L-arginine methyl ester hydrochloride;NG-Nitro-L-arginine-methyl ester hydrochloride;LNAME hydrochloride;L-NAME HCl;NG-Nitro-L-arginine methyl ester hydrochloride;L-NAME, HCl;L-NAME HCl;NG-NO2-L-Arg-OMe;H-Arg(NO)-OMe HCl;Nomega-NO2-L-Arg-OMe;Methyl N5-(imino(nitroamino)methyl)-L-ornithine monohydrochloride;H-Arg(NO2)-OMeHCl;methyl (2S)-2-amino-5-(3-
Cas No.	51298-62-5
分子式	C₇H₁₆ClN₅O₄
分子量	269.69
包装储存	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性

L-NAME hydrochloride inhibits NOS with an IC₅₀ of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC₅₀ value of 1.4 μM.

性状

Solid

IC50 & Target[1][2]

IC50: 70 μM (NOS)

体外研究(In Vitro)

L-arginine analogues are widely used inhibitors of nitric oxide synthase (NOS) activity, with N-nitro-L-arginine methyl ester (L-NAME) being at the head. Freshly dissolved L-NAME is a 50 fold less potent inhibitor of purified brain NOS (mean IC₅₀= 70 μM) than L-NOARG (IC₅₀= 1.4 μM), but the apparent inhibitory potency of L-NAME approached that of L-NOARG upon prolonged incubation at neutral or alkaline pH. HPLC analyses reveal that NOS inhibition by L-NAME closely correlated with hydrolysis of the drug to L-NOARG.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

L-NAME infusion significantly decreases NKT-leukocyte level, tumor-necrosis factor (TNF)-alpha production by T-splenocytes and macrophages, and IFNγ production by T-leukocytes, monocytes, and T-splenocytes, as well as increased interleukin-6 production by T-leukocytes and monocytes and nitrate/nitrite production by T-leukocytes. There is increasing evidence that nitric oxide may be involved in learning and memory. l-NAME produces a task-dependent impairment of fear extinction, and implies that nitric oxide signaling is involved in memory process of certain fear extinction tasks. Chronic L-NAME administration induces cardiac hypertrophy in rodent models. Six weeks L-NAME administration induces significant cardiac hypertrophy compared to control hearts.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Pfeiffer S, et al. Inhibition of nitric oxide synthesis by NG-nitro-L-arginine methyl ester (L-NAME): requirement forbioactivation to the free acid, NG-nitro-L-arginine. Br J Pharmacol. 1996 Jul;118(6):1433-40. [Information]

[2]. Kopincová J, et al. L-NAME in the cardiovascular system - nitric oxide synthase activator? Pharmacol Rep. 2012;64(3):511-20. [Information]

[3]. Lo HC, et al. The Nitric Oxide Synthase Inhibitor NG-Nitro-L-Arginine Methyl Ester Diminishes the Immunomodulatory Effects of Parental Arginine in Rats with Subacute Peritonitis. PLoSOne. 2016 Mar 23;11(3):e0151973. [Information]

[4]. Luo H, et al. Effect of nitric oxide synthase inhibitor L-NAME on fear extinction in rats: a task-dependent effect. Neurosci Lett. 2014 Jun 20;572:13-8. [Information]

[5]. Ocsan RJ, et al. Chronic NG-nitro-l-arginine methyl ester (L-NAME) administration in C57BL/6J mice induces a sustained decrease in c-kit positive cells during development of cardiac hypertrophy. J Physiol Pharmacol. 2013 Dec;64(6):727-36. [Information]

溶解度数据

体外研究:

DMSO : 100 mg/mL (370.80 mM; Need ultrasonic)

H₂O : 100 mg/mL (370.80 mM; Need ultrasonic)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.7080 mL	18.5398 mL	37.0796 mL
5 mM	0.7416 mL	3.7080 mL	7.4159 mL
10 mM	0.3708 mL	1.8540 mL	3.7080 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： PBS
Solubility: 140 mg/mL (519.11 mM); Clear solution; Need ultrasonic

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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