Sirt1和Sirt3抑制剂,4'-bromo-Resveratrol is a Sirt1 and Sirt3 inhibitor.Sirtuins are protein deacetylases regulating aging processes and many physiological functions. Resveratrol activates human Sirt1 and inhibits Sirt3, and can mimic calorie restriction effec
4-Bromo-resveratrol is a potent and dual inhibitor Sirtuin-1 and Sirtuin-3. 4-Bromo-resveratrol inhibits melanoma cell growth through mitochondrial metabolic reprogramming. 4-Bromo-resveratrol imparts antiproliferative effects in melanoma cells through a metabolic reprogramming and affecting the cell cycle and apoptosis signaling.