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C-type natriuretic peptide (1-22) (human, rat, swine)

利尿钠肽受体NPR2（NPRB）激动剂，C-Type Natriuretic Peptide (CNP) (1-22), human人是C-型钠尿肽的1-22片段。 C-type natriuretic peptide是利尿钠肽家族肽，其参与维持电解质-液体平衡和血管张力。

目录号: PC15064 纯度: ≥98%

CAS No. :127869-51-6

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中文名称

C-type natriuretic peptide (1-22) (human, rat, swine)

中文别名

C-型利尿钠肽 1-22;NATRIURETIC PEPTIDE, C-TYPE

英文名称

C-type natriuretic peptide (1-22) (human, rat, swine)

英文别名

C-Type natriureticpeptide-22 (swine) (9CI);Cortistatin (Rat);C-type Natriuretic Peptide (Human)(Source:Porcine, Rat);C-type natriuretic peptide (1-22) (human, rat, swine);C-Type Natriuretic Peptide (32-53) (human, porcine, rat);C-Type Natriuretic Peptide (32-53) (human, porcine, rat) ,CNP-22 (human, porcine, rat);Natriuretic peptide, C-type;CNP;C-Type natriuretic peptide;Dihydrexidine hydrochloride;GLY-LEU-SER-LYS-GLY-CYS-PHE-GLY-LEU-LYS-LEU-ASP-ARG-ILE-GLY-SER-MET-SER-GLY-LEU-GLY-CYS: GLSKGCFGLKLDRIGSMSGLGCDISULFIDE BRIDGE CYS6-CYS22;GLY-LEU-SER-LYS-GLY-CYS-PHE-GLY-LEU-LYS-LEU-ASP-ARG-ILE-GLY-SER-MET-SER-GLY-LEU-GLY-CYS(DISULFIDE BRIDGE:CYS6-CYS22);C-Type natriuretic factor-22 (pig);Human C-type natriuretic peptide(1-22);Human CNP-22;Porcine C-type natriuretic peptide(1-22);Rat C-type natriuretic peptide(1-22);CNP2;CNP-22, HUMAN;CNP(1-22)【human】;CNP(1-22)【porcine】;Atriopeptin C (pig);HuMan CNP-22 Peptide;GLSKGCFGLKLDRIGSMSGLGC;natriureticpeptide,c-type;C-Type Natriuretic Peptide (CNP) (1-22), human

Cas No.

127869-51-6

分子式

C₉₃H₁₅₇N₂₇O₂₈S₃

分子量

2197.60

包装储存

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性

C-Type Natriuretic Peptide (CNP) (1-22), human, a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor.

性状

Solid

IC50 & Target[1][2]

NPR-B

体外研究(In Vitro)

C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) (0.01, 0.1, 1, 10, 100, 1000 nM) increases cGMP production in CHO cells expressing human NPR-B in a concentration-dependent manner.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

PK parameters of CNP immunoreactivity after a single intravenous administration of C-Type Natriuretic Peptide (CNP) (1-22), human:

Dose (nM/kg)	AUC_0-∞ (pM·min/mL)	MRT_0-∞ (min)	T_1/2 (min)	CL_tot (mL/min/kg)	Vd_ss (mL/kg)
20	320±54	1.02±0.18	1.42±0.45	63.9±11.9	64.2±5.1

PK parameters of CNP immunoreactivity after a single subcutaneous administration of C-Type Natriuretic Peptide (CNP) (1-22), human:

Dose (nM/kg)	Cmax (pM/mL)	Tmax (min)	AUC_0-∞ (pM·min/mL)	MRT_0-∞ (min)	T_1/2 (min)	BA (%)
50	9.02±3.74	5.0±0.0	152±73	13.9±3.4	10.0±5.0	19±9

Each value represents the mean±SD of 3 rats. MRT=mean residence time, CL_tot=total clearance, T_1/2=half-life period, BA=bioavailability.
i.c.v. administration of C-Type Natriuretic Peptide (CNP) (1-22) in a dose of 2 nM induces an increase in the severity of picrotoxin-kindled convulsions 24 and 48 hrs after application of the peptide.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

SequenceShortening

GLSKGCFGLKLDRIGSMSGLGC (Disulfide bridge: Cys6-Cys22)

Sequence

Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys (Disulfide bridge: Cys6-Cys22)

参考文献

[1]. Morozumi N, et al. ASB20123: A novel C-type natriuretic peptide derivative for treatment of growth failure and dwarfism. PLoS One. 2019 Feb 22;14(2):e0212680. [Information]

[2]. Buckley MG, et al. Circulating C-type natriuretic peptide is increased in orthotopic cardiac transplant recipients and associated with cardiac allograft vasculopathy. Clin Sci (Lond). 2000 Nov;99(5):467-72. [Information]

[3]. Mazarati AM, et al. ANP(1-28), BNP(1-32) and CNP(1-22) increase the severity of picrotoxin-kindled seizure syndrome in rats. Life Sci. 1993;52(3):PL19-24. [Information]

溶解度数据

体外研究:

H₂O : 10 mg/mL (4.55 mM; Need ultrasonic)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.4550 mL	2.2752 mL	4.5504 mL
5 mM	---	---	---
10 mM	---	---	---

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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